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ChemicalBook--->CAS DataBase List--->188844-34-0

188844-34-0

188844-34-0 Structure

188844-34-0 Structure
IdentificationBack Directory
[Name]

HX 531
[CAS]

188844-34-0
[Synonyms]

HX 531
HX531 >=98% (HPLC)
4-(7,8,9,10-Tetrahydro-5,7,7,10,10-pentamethyl-2-nitro-5H-benzo[b]naphtho[2,3-e][1,4]diazepin-12-yl)benzoic acid
[Molecular Formula]

C29H29N3O4
[MDL Number]

MFCD19690920
[MOL File]

188844-34-0.mol
[Molecular Weight]

483.56
Chemical PropertiesBack Directory
[Boiling point ]

656.2±55.0 °C(Predicted)
[density ]

1.27±0.1 g/cm3(Predicted)
[storage temp. ]

2-8°C
[solubility ]

DMF:15.0(Max Conc. mg/mL);31.02(Max Conc. mM)
DMF:PBS (pH 7.2) (1:6):0.14(Max Conc. mg/mL);0.29(Max Conc. mM)
DMSO:17.67(Max Conc. mg/mL);36.53(Max Conc. mM)
Ethanol:0.12(Max Conc. mg/mL);0.25(Max Conc. mM)
[form ]

A crystalline solid
[pka]

3.70±0.10(Predicted)
[color ]

Light yellow to orange
Safety DataBack Directory
[Symbol(GHS) ]


GHS07
[Signal word ]

Warning
[Hazard statements ]

H315-H319
[Precautionary statements ]

P302+P352-P305+P351+P338
Hazard InformationBack Directory
[Uses]

HX 531 is a novel RXR antagonist used to enhance transactivation of PPARγ and ST 13 preadipocyte differentiation. Helps in the reduction of triglyceride content in white adipose tissue, skeletal muscle and liver.
[Biological Activity]

HX-531 is a potent antagonist of the retinoid X receptor (RXR) with an IC50 value of 18 nM. HX531 has been used in many studies of the various effects of retinoids and RXR activity in diseases such as diabetesParkinsonμs diseaseoften as a control for agonists such as Bexarotene. It was recently shown to promote white adipogenic differentiation and inhibit both basal and Bexarotene-induced brown adipogenic differentiation.
[storage]

Store at +4°C
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