| Identification | Back Directory | [Name]
Methyl 3-bromo-5-iodobenzoate | [CAS]
188813-07-2 | [Synonyms]
Methyl 5-bromo-3-iodobenzoate
Methyl3-bromo-5-iodobenzoate97%
Methyl 3-bromo-5-iodobenzoate 97%
Benzoic acid, 3-bromo-5-iodo-, meth
3-BroMo-5-iodobenzoic acid Methyl ester
Benzoic acid,3-broMo-5-iodo-, Methyl ester | [Molecular Formula]
C8H6BrIO2 | [MDL Number]
MFCD00673016 | [MOL File]
188813-07-2.mol | [Molecular Weight]
340.94 |
| Chemical Properties | Back Directory | [Melting point ]
62.0-63.0 °C | [Boiling point ]
334.5±32.0 °C(Predicted) | [density ]
2.059±0.06 g/cm3(Predicted) | [storage temp. ]
RT, protect from light | [form ]
Powder | [Appearance]
White to off-white Solid |
| Hazard Information | Back Directory | [Synthesis]
(a) Synthesis of methyl 3-bromo-5-iodobenzoate: In a dry reaction flask, 3-bromo-5-iodobenzoic acid (15 g, 45.9 mmol) was dissolved in a solvent mixture of tetrahydrofuran (20 mL) and N,N-dimethylformamide (75 mL). Sodium carbonate (9.7 g, 92 mmol) and iodomethane (5.7 mL, 92 mmol) were then added. The reaction mixture was stirred at room temperature for 20 hours. After completion of the reaction, most of the solvent was removed by concentration under reduced pressure. The residue was extracted with ethyl acetate and washed sequentially with water, saturated aqueous sodium bicarbonate solution and brine. The organic phase was dried over anhydrous sodium sulfate and concentrated under reduced pressure to give the title compound methyl 3-bromo-5-iodobenzoate. Yield: 15 g (99% yield). | [References]
[1] Patent: WO2010/103279, 2010, A1. Location in patent: Page/Page column 126
[2] Patent: WO2010/103297, 2010, A2. Location in patent: Page/Page column 71 |
|
|