| Identification | Back Directory | [Name]
PI4KIII beta inhibitor 1 | [CAS]
1881233-39-1 | [Synonyms]
PI4KIIIbeta-IN-10
PI4KIII beta inhibitor 1
N-(5-(3-(N-(4-HYDROXYPHENYL)SULFAMOYL)-4-METHOXYPHENYL)-4-METHYLTHIAZOL-2-YL)PIVALAMIDE
N-[5-[3-[(4-hydroxyphenyl)sulfamoyl]-4-methoxyphenyl]-4-methyl-1,3-thiazol-2-yl]-2,2-dimethylpropanamide
Propanamide, N-[5-[3-[[(4-hydroxyphenyl)amino]sulfonyl]-4-methoxyphenyl]-4-methyl-2-thiazolyl]-2,2-dimethyl- | [Molecular Formula]
C22H25N3O5S2 | [MDL Number]
MFCD30187514 | [MOL File]
1881233-39-1.mol | [Molecular Weight]
475.58 |
| Chemical Properties | Back Directory | [density ]
1.367±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : ≥ 30 mg/mL (63.08 mM) | [form ]
Solid | [pka]
9.06±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
PI4KIIIbeta-IN-10 is a potent PI4KIIIβ inhibitor with an IC50 of 3.6 nM. | [Biological Activity]
PI4KIII beta inhibitor 1 is a potent PI4KIIIβ inhibitor with IC50 of 3.6 nM. | [in vitro]
PI4KIII beta inhibitor 1 is a potent PI4KIIIβ inhibitor with very minor off-target inhibition of PI4KIIIβ related lipid kinases. PI4KIIIbeta-IN-10 shows weak inhibition of PI3KC2γ (IC 50 < /sub> ~1 μM), PI3Kα (~10 μM), and PI4KIIIα (~3 μM), and <20% inhibition at concentrations up to 20 μM for PI4K2α, PI4K2β, and PI3Kβ. | [target]
| PI4KIIIβ 3.6 nM (IC 50 ) | PI4KIIIα 3 μM (IC 50 ) | PI3Kδ 720 nM (IC 50 ) | PI3KC2γ 1 μM ( IC 50 ) | PI3Kα 10 μM (IC 50 ) | PI3Kγ 20 μM (IC < sub> 50 ) | | [IC 50]
PI4KIIIβ: 3.6 nM (IC50); PI4KIIIα: 3 μM (IC50); PI3Kδ: 720 nM (IC50); PI3KC2γ: 1 μM (IC50); PI3Kα: 10 μM (IC50); PI3Kγ: 20 μM (IC50) | [storage]
Store at -20°C | [References]
[1] Rutaganira FU, et al. Design and Structural Characterization of Potent and Selective Inhibitors of Phosphatidylinositol 4 Kinase IIIβ. J Med Chem. 2016 Mar 10;59(5):1830-9. DOI:10.1021/acs.jmedchem.5b01311 |
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| Company Name: |
Musechem
|
| Tel: |
+1-800-259-7612 |
| Website: |
www.musechem.com |
| Company Name: |
Twochem Co.Ltd.
|
| Tel: |
021-58111628 15800915896 |
| Website: |
cn.twochem.com |
|