| Identification | Back Directory | [Name]
(3S)-3-(5-chloro-2-methoxy-phenyl)-3-fluoro-6-(trifluoromethyl)-1H-ind ol-2-one | [CAS]
187523-35-9 | [Synonyms]
MaxiPost
FLINDOKALNER
BMS-204352
(BMS 204352
(3S)-3-(5-chloro-2-methoxy-phenyl)-3-fluoro-6-(trifluoromethyl)-1H-ind ol-2-one
(3S)-3-(5-Chloro-2-methoxyphenyl)-3-fluoro-1,3-dihydro-6-(trifluoromethyl)-2H-Indol-2-one
2H-Indol-2-one, 3-(5-chloro-2-methoxyphenyl)-3-fluoro-1,3-dihydro-6-(trifluoromethyl)-, (3S)- | [Molecular Formula]
C16H10ClF4NO2 | [MDL Number]
MFCD09475617 | [MOL File]
187523-35-9.mol | [Molecular Weight]
359.7 |
| Chemical Properties | Back Directory | [Boiling point ]
436.9±45.0 °C(Predicted) | [density ]
1.50±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble to 100 mM in DMSO and to 100 mM in ethanol | [form ]
Powder | [pka]
10.43±0.40(Predicted) | [color ]
White to off-white | [InChI]
InChI=1S/C16H10ClF4NO2/c1-24-13-5-3-9(17)7-11(13)15(18)10-4-2-8(16(19,20)21)6-12(10)22-14(15)23/h2-7H,1H3,(H,22,23)/t15-/m0/s1 | [InChIKey]
ULYONBAOIMCNEH-HNNXBMFYSA-N | [SMILES]
N1C2=C(C=CC(C(F)(F)F)=C2)[C@@](C2=CC(Cl)=CC=C2OC)(F)C1=O |
| Hazard Information | Back Directory | [Uses]
Neuroprotectant (opener of large conductance, calcium-activated (maxi-K) K+channels. | [Biological Activity]
BMS 204352 (MaxiPost [(3S)-(+)-(5-chloro-2-methoxyphenyl)-1,3-dihydro-3-fluoro-6-(trifluoromethyl)-2H-indole-2-one)] is used to tre at ischemic stroke. It also acts as an activator of KNCQ4 (KQT-like subfamilymember 4) and KCNQ5 (KQT-like subfamilymember 5) with equal potency.''BMS 204352 is a potassium channel modulator. Originally developed as a potent opener of large-conductancecalcium-activated (Maxi-KKCa1.1BK) potassium channelsBMS 204352 also acts as a positive modulator at Kv7 (KCNQ) channels. | [in vivo]
Flindokalner (BMS-204352) (3-30 mg/kg; i.p.) induces a dose-dependent anxiolytic effect[1].
In shock-based conditioned model of anxiety in male Wistar rats, Flindokalner (3-60 mg/kg; i.p.) engenderes an anxiolytic profile[1]. | Animal Model: | Female NMRI or male C57 mice (20-25 g) (Anxiolytic Models)[1] | | Dosage: | i.p. | | Administration: | 3, 10, 30 mg/kg | | Result: | Significantly and dose dependently increased time spent in the open areas, reduced latency to enter an open area, and increased the number of entries in to the open areas in Zero Maze. |
| [storage]
Store at -20°C |
|
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
|