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ChemicalBook--->CAS DataBase List--->1872466-47-1

1872466-47-1

1872466-47-1 Structure

1872466-47-1 Structure
IdentificationBack Directory
[Name]

CM-675
[CAS]

1872466-47-1
[Synonyms]

CM-675
[Molecular Formula]

C31H32N6O3
[MDL Number]

MFCD32067899
[MOL File]

1872466-47-1.mol
[Molecular Weight]

536.62
Chemical PropertiesBack Directory
[density ]

1.29±0.1 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[solubility ]

DMSO : 25 mg/mL (46.59 mM; ultrasonic and warming and heat to 60°C)
[form ]

Solid
[pka]

13.23±0.70(Predicted)
[color ]

Off-white to gray
Hazard InformationBack Directory
[Uses]

CM-675 is a dual phosphodiesterase 5 (PDE5) and class I histone deacetylases-selective inhibitor, with IC50 values of 114 nM and 673 nM for PDE5 and HDAC1, respectively. CM-675 has potential to treat Alzheimer’s disease[1].
[Biological Activity]

CM-675 is a dual phosphodiesterase 5 (PDE5) and class I histone deacetylases-selective inhibitor, with IC50 values of 114 nM and 673 nM for PDE5 and HDAC1, respectively. CM-675 has potential to treat Alzheimer's disease[1]. CM-675 (29a) shows a significant time-dependent effect on class I HDAC inhibition, particularly towards HDAC2. For HDAC1, its inhibitory potency also increased significantly (~1 log unit) with the pre-incubation time: 673 nM (30 min), 180 nM (4 hours) and 69 nM (6 hours) [1].
[IC 50]

HDAC1: 673 nM (IC50, 30 min (time-dependent)); PDE5: 114 nM nM (IC50)
[storage]

Store at -20°C
[References]

[1]. Rabal O, et al. Discovery of in Vivo Chemical Probes for Treating Alzheimer's Disease: Dual Phosphodiesterase 5 (PDE5) and Class I Histone Deacetylase Selective Inhibitors. ACS Chem Neurosci. 2019 Mar 20;10(3):1765-1782.
Spectrum DetailBack Directory
[Spectrum Detail]

CM-675(1872466-47-1)1HNMR
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