| Identification | Back Directory | [Name]
4,7,10,13,16-Pentaazanonadecanedioic acid, 4,10,16-tris[3-[2-[2-methyl-3-(octylthio)-1-oxopropoxy]ethoxy]-3-oxopropyl]-, 1,19-bis[2-[2-methyl-3-(octylthio)-1-oxopropoxy]ethyl] ester | [CAS]
1857341-90-2 | [Synonyms]
4,7,10,13,16-Pentaazanonadecanedioic acid, 4,10,16-tris[3-[2-[2-methyl-3-(octylthio)-1-oxopropoxy]ethoxy]-3-oxopropyl]-, 1,19-bis[2-[2-methyl-3-(octylthio)-1-oxopropoxy]ethyl] ester | [Molecular Formula]
C93H173N5O20S5 | [MOL File]
1857341-90-2.mol | [Molecular Weight]
1841.72 |
| Chemical Properties | Back Directory | [Boiling point ]
1296.6±65.0 °C(Predicted) | [density ]
1.077±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [form ]
Oil | [pka]
9.51±0.19(Predicted) | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Uses]
5A2-SC8 is an ionizable amino lipid in lipid nanoparticles (LNPs) that shows high delivery potential and low in vivo toxicity, enabling efficient delivery of small RNAs such as siRNA and miRNA into tumor cells. 5A2-SC8 LNPs can confer a unique delivery fate of RNA within the liver, thereby changing the therapeutic outcomes in cancer models[1][2][3]. | [Biological Activity]
5A2-SC8 is a degradable lipid-like compound (ester-based dendrimer) for small RNAs delivery. | [in vivo]
5A2-SC8 (75 mg/kg; i.v.; single-dose) is well tolerated and does not affect survival in mice with chronic aggressive hepatocellular carcinoma[1].
5A2-SC8 (0.5 mg/kg; i.v.; single-dose) can pass the first barrier of Kupffer cells in the liver and be internalized into hepatocytes in the presence of siFVII labeled with Cy5.5 dye[2]. | [References]
[1]. Zhou K, Nguyen LH, Miller JB, et al. Modular degradable dendrimers enable small RNAs to extend survival in an aggressive liver cancer model. Proc Natl Acad Sci U S A. 2016;113(3):520-525. |
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DC Chemicals
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021-8447131 13564518121 |
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