| Identification | Back Directory | [Name]
DO-34
(DO34) | [CAS]
1848233-58-8 | [Synonyms]
DO-34
(DO34)
1-Piperazinecarboxylic acid, 3-(phenylmethyl)-4-[[4-[4-(trifluoromethoxy)phenyl]-1H-1,2,3-triazol-1-yl]carbonyl]-, 1,1-dimethylethyl ester
DO34 3-(Phenylmethyl)-4-[[4-[4-(trifluoromethoxy)phenyl]-1H-
1,2,3-triazol-1-yl]carbonyl]-1-piperazinecarboxylic acid
1,1-dimethylethyl ester | [Molecular Formula]
C26H28F3N5O4 | [MDL Number]
MFCD31807614 | [MOL File]
1848233-58-8.mol | [Molecular Weight]
531.53 |
| Chemical Properties | Back Directory | [Boiling point ]
611.4±65.0 °C(Predicted) | [density ]
1.32±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : ≥ 100 mg/mL (188.14 mM) | [form ]
Solid | [pka]
-0.68±0.70(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Biological Activity]
DO34 is a brain-penetrantselective and highly potent diacylglycerol lipase inhibitor (recom human DAGLα/β pIC50 = 8.2/8.1 by SAG hydrolysis; mouse brain DAGLα/β pIC50 = 9.1-9.3/8.6 by ABPP ReDiMe) with detectable off-target activity toward only ABHD6 & PLA2G7 among all mouse brain serine hydrolases and little affinity toward cannabinoid receptors CB1/2. DO34 blocks depolarization-induced suppression of excitation (DSE IC50 = 0.18 μM) and inhibition (100% DSI blockage at 1 μM) in mouse cerebellar and hippocampal slices ex vivoand attenuate LPS-induced neuroinflammatory responses by lowering brain 2-AG & PGE2 level in mice in vivo (50 mg/kgi.p). |
|
| Company Name: |
Merck KGaA
|
| Tel: |
(+86) 21 2033 8288 |
| Website: |
http://www.sigmaaldrich.cn |
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