| Identification | Back Directory | [Name]
N-(4-Fluorobenzoyl)-5-aMino-1H-indole | [CAS]
182564-41-6 | [Synonyms]
OAC3
OAC3,OAC-3
Oct4 inducer-1
4-fluoro-N-(1H-indol-5-yl)benzamide
N-(4-Fluorobenzoyl)-5-aMino-1H-indole | [Molecular Formula]
C15H11FN2O | [MDL Number]
MFCD03055941 | [MOL File]
182564-41-6.mol | [Molecular Weight]
254.26 |
| Chemical Properties | Back Directory | [Boiling point ]
374.9±22.0 °C(Predicted) | [density ]
1.374±0.06 g/cm3(Predicted) | [solubility ]
DMF: 20 mg/ml; DMF:PBS(pH 7.2)(1:1): 0.50 mg/ml; DMSO: 16 mg/ml; Ethanol: 12.5 mg/ml | [form ]
A crystalline solid | [pka]
13.86±0.43(Predicted) | [color ]
Light brown to brown |
| Hazard Information | Back Directory | [Uses]
N-(4-Fluorobenzoyl)-5-amino-1H-indole is a octamer-binding transcription factor 4 activating compound that activated Oct4 and Nanog promoters, which are essential regulators of embryonic stem cell (ESC) pluripotency and key to the reprogramming process. | [Uses]
Octamer-binding transcription factor 4 (Oct4) is a transcription factor which, with Sox2, Klf4, and c-Myc, is involved in the reprogramming of somatic cells to produce pluripotent stem cells. OAC3 is an Oct4-activating compound which activates expression through the Oct4 gene promoter. In cells expressing Oct4 with Sox2, Klf4, and c-Myc, OAC3 (1 μM) enhances reprogramming efficiency by increasing the rate of production of induced pluripotent stem cells from embryonic fibroblasts.[Cayman Chemical] |
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