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ChemicalBook--->CAS DataBase List--->182133-27-3

182133-27-3

182133-27-3 Structure

182133-27-3 Structure
IdentificationBack Directory
[Name]

ARZOXIFENE HCL
[CAS]

182133-27-3
[Synonyms]

Serm 3
Ly 353381
Ly 353381 HCl
ARZOXIFENE HCL
Arzoxifene hydrochloride
NHSNLUIMAQQXGR-UHFFFAOYSA-N
2-(4-Methoxyphenyl)-3-(4-(2-(1-piperidinyl)ethoxy)phenoxy)benzo(B)thiophene-6-ol hydrochloride
2-(p-Methoxyphenyl)-3-(p-(2-(1-piperidinyl)ethoxy)phenoxy)benzo(B)thiophene-6-ol hydrochloride
Benzo(B)thiophene-6-ol, 2-(4-methoxyphenyl)-3-(4-(2-(1-piperidinyl)ethoxy)phenoxy)-, hydrochloride
[Molecular Formula]

C28H29NO4S.ClH
[MDL Number]

MFCD00954651
[MOL File]

182133-27-3.mol
[Molecular Weight]

512.067
Chemical PropertiesBack Directory
[Melting point ]

156-160°
[form ]

Solid
[color ]

Off-white to light yellow
Hazard InformationBack Directory
[Uses]

Treatment of symptoms associated with uterine fibroids, endometriosis, and dysfunctional uterine bleeding; in the treatment of estrogen receptor positive recurrent/metastatic breast cancer; as an adjuvant to breast cancer therapy (selective estrogen recep.
[in vivo]

Arzoxifene prevents the ovariectomy-induced increase in body weight and serum cholesterol levels of treated rats and lowers them to below sham levels in a dose dependent manner, with maximum efficacy similar to estrogen or raloxifene. Arzoxifene (LY353381.HCl) prevents loss of bone due to ovariectomy with an ED50 of about 0.01 mg/kg with maximal efficacy observed at 0.1-1 mg/kg/day. Arzoxifene (LY353381.HCl) antagonizes the estrogen-induced elevation in uterine weight down to vehicle-dosed control levels with ED50 of 0.03 mg/kg/day[2].

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