天堂网亚洲,天天操天天搞,91视频高清,菠萝蜜视频在线观看入口,美女视频性感美女视频,95丝袜美女视频国产,超高清美女视频图片

ChemicalBook--->CAS DataBase List--->1819363-80-8

1819363-80-8

1819363-80-8 Structure

1819363-80-8 Structure
IdentificationBack Directory
[Name]

PFI3
[CAS]

1819363-80-8
[Synonyms]

PFI3
PFI-3
CS-1803
PFI3; PFI 3
PFI3 USP/EP/BP
(2E)-1-(2-Hydroxyphenyl)-3-[(1R,4R)-5-(2-pyridinyl)-2,5-diazabicyclo[2.2.1]hept-2-yl]-2-propen-1-one
(E)-1-(2-Hydroxyphenyl)-3-((1R,4R)-5-(pyridin-2-yl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)prop-2-en-1-one
(2E)-1-(2-Hydroxyphenyl)-3-[(1R,4R)-5-(pyridin-2-yl)-2,5-diazabicyclo[2.2.1]heptan-2-yl]prop-2-en-1-one
2-Propen-1-one, 1-(2-hydroxyphenyl)-3-[(1R,4R)-5-(2-pyridinyl)-2,5-diazabicyclo[2.2.1]hept-2-yl]-, (2E)-
[Molecular Formula]

C19H19N3O2
[MDL Number]

MFCD28100807
[MOL File]

1819363-80-8.mol
[Molecular Weight]

321.373
Chemical PropertiesBack Directory
[storage temp. ]

2-8°C
[solubility ]

Soluble in DMSO (>25 mg/ml)
[form ]

powder
[color ]

yellow to orange
[Stability:]

Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Safety DataBack Directory
[WGK Germany ]

3
Hazard InformationBack Directory
[Description]

PFI-3 (1819363-80-8) is a selective inhibitor of family VIII bromodomains PB1(5), SMARCA2, and SMARCA4.1 It showed complete selectivity over all non-family VIII bromodomains.? PFI-3 blocked adipogenesis in C3H10T1/2 mesenchymal cells at 20μM.Treatment of embryonic stem cells with PFI-3 led to deprivation of stemness and deregulated lineage specificity. Differentiation of trophoblast stem cells in the presence of PFI-3 was enhanced.2 Cell permeable.
[Uses]

PFI-3 is a selective chemical inhibitor for SMARCA (2/4) and PBI (5) bromodomains which may result in the delay and prevention of breast cancer.
[Definition]

ChEBI: PFI-3 is an azabicycloalkane that is (1R,4R)-2,5-diazabicyclo[2.2.1]heptane which is substituted at position 2 by a 3-(2-hydroxyphenyl)-3-oxoprop-1-en-1-yl group and at position 5 by a pyridin-2-yl group. It is a potent and selective inhibitor of polybromo 1 (Kd = 48 nM), SMARCA2 and SMARCA4 (Kd = 89 nM) bromodomains. It is a member of pyridines, an azabicycloalkane, a member of phenols and an enone.
[Biochem/physiol Actions]

SMARCA4 (SWI/SNF related, Matrix associated, Actin dependent Regulator of Chromatin, subfamily A, member 4) is a transcriptional activator and is a component of the large ATP-dependent chromatin remodeling complex SWI/SNF, which is required for transcriptional activation of genes normally repressed by chromatin. SMARC4 (also known as BRG1) and the related protein SMARCA2 (also known as BRM) contain a bromodomain that is structurally similar to the PolyBromo1 (PB1) 5 bromodomain. PFI-3 is a selective chemical probe for SMARCA bromodomains that inhibits SMARCA2, SMARCA4 and PB1(5) bromodomains. For full characterization details, please visit the PFI-3 probe summary on the Structural Genomics Consortium (SGC) website.To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc
[storage]

Store at -20°C
[References]

Gerstenberger et al. (2016), Identification of a chemical probe for family VIII bromodomains through optimization of a fragment hit; J. Med. Chem. 59 4800 Fedorov et al. (2015), Selective targeting of the BRG/PB1 bromodomains impairs embryonic and trophoblast stem cell maintenance; Sci. Adv. 1 e1500723
Spectrum DetailBack Directory
[Spectrum Detail]

PFI3(1819363-80-8)1HNMR
1819363-80-8 suppliers list
Company Name: ATK CHEMICAL COMPANY LIMITED
Tel: +undefined-21-51877795
Website: www.atkchemical.com
Company Name: BOC Sciences
Tel: +1-631-485-4226
Website: www.bocsci.com/
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354 +1-00000000000 , +1-00000000000
Website: https://www.targetmol.com/
Company Name: HANGZHOU CLAP TECHNOLOGY CO.,LTD
Tel: 86-571-88216897,88216896 13588875226 , 13588875226
Website: www.hzclap.com/en
Company Name: Wuxi Rejoys chemical Technology Co., Ltd.
Tel: 0510-86103381
Website: www.rejoyschem.com
Company Name: Dideu Industries Group Limited
Tel: +86-29-89586680 +86-15129568250 , +86-15129568250
Website: https://www.dideu.com
Company Name: InvivoChem
Tel: +1-708-310-1919 +1-13798911105 , +1-13798911105
Website: https://www.invivochem.com/
Company Name: TargetMol Chemicals Inc.
Tel:
Website: www.targetmol.com/
Company Name: ShenZhen Trendseen Biological Technology Co.,Ltd.
Tel: 13417589054 , 13417589054
Website: m.approvedhomemanagement.com/ShowSupplierProductsList1962465/0.htm
Company Name: Jilin Chinese Academy of Sciences-yanshen Technology
Tel: +undefined18143011203 , +undefined18143011203
Website: www.chemextension.com/
Company Name: Aladdin Scientific
Tel:
Website: www.aladdinsci.com/
Company Name: Wuhan Jingkang en Biomedical Technology Co., Ltd
Tel: +8613720134139 , +8613720134139
Website: http://www.jknbiochem.com/
Company Name: Amadis Chemical Company Limited
Tel: 571-89925085
Website: http://www.amadischem.com
Company Name: Chengdu Henghui Pharmaceutical Co., Ltd.
Tel: 86-028-89481236 13540674322 15828370308
Website: m.approvedhomemanagement.com/ShowSupplierProductsList30420/0.htm
Company Name: ROSEWA HOLDING GROUP CO.,LIMITED
Tel: +86-023-62871537
Website: m.approvedhomemanagement.com/ShowSupplierProductsList31018/0.htm
Company Name: Chengdu Henghui Pharm Tec Co. Ltd.  
Tel: 13540674322 15828370308
Website: m.approvedhomemanagement.com/ShowSupplierProductsList30422/0.htm
Company Name: Shanghai Boyle Chemical Co., Ltd.  
Tel:
Website: www.boylechem.com
Company Name: ShangHai Caerulum Pharma Discovery Co., Ltd.  
Tel: 18149758185 18149758185
Website: www.caerulumpharma.com
Tags:1819363-80-8 Related Product Information
57444-62-9 220620-09-7 1124329-14-1 923978-27-2 1314241-44-5 179324-69-7 1477949-42-0 1005342-46-0 49843-98-3 919973-83-4

This site uses cookies
This website uses cookies and similar technologies to store and retrieve information about your use of this website. This information helps us to provide, analyse and improve our services, which may include personalised content or advertising. We may share this information with Google and other third parties. This cookies are necessary for our website to work properly . By clicking "Continue" or continuing to browse our site you are agreeing to our and our partners use of cookies.
Accept