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ChemicalBook--->CAS DataBase List--->1815580-06-3

1815580-06-3

1815580-06-3 Structure

1815580-06-3 Structure
IdentificationBack Directory
[Name]

HDAC6-IN-1
[CAS]

1815580-06-3
[Synonyms]

SKLB-23bb
HDAC6-IN-1
Butanamide, N-hydroxy-4-[2-methoxy-5-[methyl(2-methyl-4-quinazolinyl)amino]phenoxy]-
[Molecular Formula]

C21H24N4O4
[MDL Number]

MFCD30533607
[MOL File]

1815580-06-3.mol
[Molecular Weight]

396.44
Chemical PropertiesBack Directory
[density ]

1.271±0.06 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[solubility ]

DMSO: Soluble
[form ]

A solid
[pka]

9.32±0.20(Predicted)
[color ]

White to off-white
Safety DataBack Directory
[Symbol(GHS) ]


GHS07
[Signal word ]

Warning
[Hazard statements ]

H302-H315-H319-H335
[Precautionary statements ]

P261-P305+P351+P338
Hazard InformationBack Directory
[Uses]

SKLB-23bb is an orally bioavailable and selective HDAC6 inhibitor with IC50 of less than 100 nM in most cell lines tested; it can be used to disrupt microtubule activity.

[in vitro]

SKLB-23bb has toxic effects at low submolar levels in a range of solid and hematological tumor cell lines. Unlike reported selective HDAC6 inhibition, SKLB-23bb is more potent against solid tumors. SKLB-23bb selectively inhibits intracellular HDAC6, but its antitumor activity is independent of HDAC6. It can bind to the colchicine site of β-tubulin and is a microtubule polymerization inhibitor. SKLB-23bb also can arrest tumor cells in the G2-M phase and induce apoptosis.

[in vivo]

In a solid tumor model, oral administration of SKLB-23bb can effectively inhibit tumor growth. It has favorable pharmacokinetic properties and is orally active.

[target]

TargetValue
HDAC6
(Cell-based assay)
<100 nM
Spectrum DetailBack Directory
[Spectrum Detail]

HDAC6-IN-1(1815580-06-3)1HNMR
1815580-06-3 suppliers list
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