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ChemicalBook--->CAS DataBase List--->180916-16-9

180916-16-9

180916-16-9 Structure

180916-16-9 Structure
IdentificationBack Directory
[Name]

Lasofoxifene
[CAS]

180916-16-9
[Synonyms]

(5R,6S)-
CP-336,156
Lasofoxifene
Lasofoxifene Base
(5R,6S)-6-phenyl-5-[4-(2-pyrrolidin-1-ylethoxy)phenyl]tetralin-2-ol
(5R,6S)-5,6,7,8-Tetrahydro-6-phenyl-5-[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]-2-naphthalenol
(5R-cis)-5,6,7,8-Tetrahydro-6-phenyl-5-[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]-2-naphthalenol
2-Naphthalenol, 5,6,7,8-tetrahydro-6-phenyl-5-[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]-, (5R,6S)-
[Molecular Formula]

C28H31NO2
[MDL Number]

MFCD09475650
[MOL File]

180916-16-9.mol
[Molecular Weight]

413.55
Chemical PropertiesBack Directory
[Melting point ]

110-113°C
[Boiling point ]

572.4±50.0 °C(Predicted)
[density ]

1.150±0.06 g/cm3(Predicted)
[storage temp. ]

Refrigerator
[solubility ]

Chloroform (Slightly), Methanol (Slightly)
[form ]

Solid
[pka]

10.31±0.60(Predicted)
[color ]

White to Off-White
Hazard InformationBack Directory
[Chemical Properties]

Off-White Solid
[Uses]

A next-generation selective estrogen receptor modulator for treating disorders associated with increased bone turnover and osteopenia.
[Definition]

ChEBI: Lasofoxifene is a member of the class of tetralins that is 5,6,7,8-tetrahydronaphthalen-2-ol in which the hydrogens at positions 5 and 6 are replaced by 4-[2-(pyrrolidin-1-yl)ethoxy]phenyl and phenyl groups, respectively (the 5R,6S-stereoisomer). It is a selective estrogen receptor modulator indicated for the prevention and treatment of osteoporosis in post-menopausal women. It has a role as an antineoplastic agent, a cardioprotective agent, an estrogen receptor agonist, an estrogen receptor antagonist and a bone density conservation agent. It is a member of tetralins, an aromatic ether, a member of naphthols and a N-alkylpyrrolidine.
[Clinical Use]

Lasofoxifene is a very potent second-generation SERM currently in phase III clinical trials for the treatment and prevention of osteoporosis in postmenopausal women.
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