| Identification | Back Directory | [Name]
4-nitrobenzaldehyde thiosemicarbazone | [CAS]
180864-33-9 | [Synonyms]
Tyrosinase-IN-2
(E)-2-(4-Nitrobenzylidene)hydrazine-1-carbothioamide
Hydrazinecarbothioamide, 2-[(4-nitrophenyl)methylene]-, (2E)- | [Molecular Formula]
C8H8N4O2S | [MOL File]
180864-33-9.mol | [Molecular Weight]
224.24 |
| Chemical Properties | Back Directory | [Melting point ]
234-235 °C (decomp) | [Boiling point ]
405.6±47.0 °C(Predicted) | [density ]
1.46±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
11.09±0.70(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
Tyrosinase-IN-2 (compound 67) is a potent inhibitor of tyrosinase. Tyrosinase is a copper-containing metalloenzyme that is responsible for the rate-limiting catalytic step in the melanin biosynthesis and enzymatic browning. Tyrosinase-IN-2 has the potential for the research of skin whitening agents and food preservatives[1]. | [References]
[1] Li J, et al. Recent advances in the design and discovery of synthetic tyrosinase inhibitors. Eur J Med Chem. 2021;224:113744. DOI:10.1016/j.ejmech.2021.113744 |
|
|