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ChemicalBook--->CAS DataBase List--->180304-07-8

180304-07-8

180304-07-8 Structure

180304-07-8 Structure
IdentificationBack Directory
[Name]

N-(2-(5-ethylbenzo[b]thiophen-3-yl)ethyl)acetamide
[CAS]

180304-07-8
[Synonyms]

S22153
S-22153
S 22153
N-(2-(5-ethylbenzo[b]thiophen-3-yl)ethyl)acetamide
Acetamide, N-[2-(5-ethylbenzo[b]thien-3-yl)ethyl]-
[Molecular Formula]

C14H17NOS
[MDL Number]

MFCD00949928
[MOL File]

180304-07-8.mol
[Molecular Weight]

247.36
Chemical PropertiesBack Directory
[storage temp. ]

Store at -20°C
[form ]

Solid
[color ]

White to off-white
Hazard InformationBack Directory
[Uses]

S-22153 is a potent melatonin receptor antagonist with EC50 values of 19 nM, 4.6 nM for hMT1 and hMT2 melatonin receptor, respectively. S-22153 has Ki values of 8.6 nM (CHO cells) and 16.3 nM (HEK cells) for hMT1, and 6.0 nM (CHO cells) and 8.2 nM (HEK cells) for hMT2. S-22153 is a specific ligand of MT1 and MT2 melatonin receptors subtypes[1][2].
[Biological Activity]

S-22153 is a potent melatonin receptor antagonist with EC50 values of 19 nM, 4.6 nM for hMT1 and hMT2 melatonin receptor, respectively. S-22153 has Ki values of 8.6 nM (CHO cells) and 16.3 nM (HEK cells) for hMT1, and 6.0 nM (CHO cells) and 8.2 nM (HEK cells) for hMT2. S-22153 is a specific ligand of MT1 and MT2 melatonin receptors subtypes[1][2]. S-22153 sets the temperature and activity periods to approximately 24 hr and increase the circadian amplitude of both rhythms in mice, which exposed to continuous light[1] .
[in vivo]

S-22153 sets the temperature and activity periods to approximately 24 hr and increase the circadian amplitude of both rhythms in mice, which exposed to continuous light[1] .

Animal Model:7 weeks old Male B6D2F1 mice, which exposed to continuous light for 10-18 days[1]
Dosage:20 mg/kg
Administration:Daily intraperitoneal (i.p.) for 19 days
Result:Set the temperature and activity periods to approximately 24 hr and increased the circadian amplitude of both rhythms in mice, which exposed to continuous light.
[IC 50]

MT1: 19 nM (EC50); MT2: 4.6 nM (EC50)
[References]

[1]. Li XM, et al. Circadian rhythm entrainment with melatonin, melatonin receptor antagonist S22153 or their combination in mice exposed to constant light. J Pineal Res. 2004;37(3):176-184. [2]. Audinot V, et al. New selective ligands of human cloned melatonin MT1 and MT2 receptors. Naunyn Schmiedebergs Arch Pharmacol. 2003;367(6):553-561.
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