| Identification | Back Directory | [Name]
(4-(2-(4-fluoro-2-methylphenoxy)-4-(trifluoromethyl)benzamido)-2-oxo-1l4,2l5-pyridin-1-yl)methyldihydrogenphosphate | [CAS]
1793080-72-4 | [Synonyms]
VX-150
EOS-62073
(4-(2-(4-fluoro-2-methylphenoxy)
-4-(trifluoromethyl)benzamido)
-2-oxopyridin-1(2H)-yl)methyl
dihydrogen phosphate
(4-(2-(4-fluoro-2-methylphenoxy)-4-(trifluoromethyl)benzamido)-2-oxo-1l4,2l5-pyridin-1-yl)methyldihydrogenphosphate
Benzamide, N-[1,2-dihydro-2-oxo-1-[(phosphonooxy)methyl]-4-pyridinyl]-2-(4-fluoro-2-methylphenoxy)-4-(trifluoromethyl)- | [Molecular Formula]
C21H17F4N2O7P | [MDL Number]
MFCD34184505 | [MOL File]
1793080-72-4.mol | [Molecular Weight]
516.34 |
| Chemical Properties | Back Directory | [density ]
1.59±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 125 mg/mL (242.09 mM; Need ultrasonic) | [form ]
Solid | [pka]
1.72±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
VX-150 is an orally active, highly selective NaV1.8 inhibitor. VX-150 has the potential for various pain indications research[1]. | [IC 50]
Nav1.8 | [References]
[1] Hemme J Hijma, et al. A Phase 1, Randomized, Double-Blind, Placebo-Controlled, Crossover Study to Evaluate the Pharmacodynamic Effects of VX-150, a Highly Selective NaV1.8 Inhibitor, in Healthy Male Adults. Pain Med. 2021 Aug 6;22(8):1814-1826. DOI:10.1093/pm/pnab032 |
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