| Identification | Back Directory | [Name]
Methyl 4-bromo-2-fluorobenzoate | [CAS]
179232-29-2 | [Synonyms]
Fluoro-4-bromobenzoate
Enzalutamide Impurity 15
Enzalutamide EP Impurity C
Methy 4-bromo-2-fluorobenzoate
Methyl 4-bromo-2-fluorobenzoate
Methyl 2-fluoro-4-bromobenzoate
4-BROMO-2-FLUOROBENZOIC ACID METHYL ESTER
2-Fluoro-4-bromobenzoic acid methyl ester
Benzoic acid, 4-bromo-2-fluoro-, methyl ester
Methyl 4-bromo-2-fluorobenzoate(For export only) | [Molecular Formula]
C8H6BrFO2 | [MDL Number]
MFCD06203731 | [MOL File]
179232-29-2.mol | [Molecular Weight]
233.04 |
| Chemical Properties | Back Directory | [Melting point ]
58-60℃ | [Boiling point ]
272.7±25.0℃ (760 Torr) | [density ]
1.577±0.06 g/cm3 (20 ºC 760 Torr) | [Fp ]
118.7±23.2℃ | [storage temp. ]
Sealed in dry,Room Temperature | [solubility ]
Chloroform (Slightly), Methanol (Slightly) | [form ]
Solid | [color ]
White to Off-White | [InChI]
InChI=1S/C8H6BrFO2/c1-12-8(11)6-3-2-5(9)4-7(6)10/h2-4H,1H3 | [InChIKey]
DLILIUSWDLJMCE-UHFFFAOYSA-N | [SMILES]
C(OC)(=O)C1=CC=C(Br)C=C1F |
| Hazard Information | Back Directory | [Chemical Properties]
off-white powder | [Uses]
4-Bromo-2-fluorobenzoic Acid Methyl Ester is the methyl ester derivative of 4-Bromo-2-fluorobenzoic Acid (B684620) and is used as a reagent in the synthesis of aminopyridyl-based inhibitors targeting Trypanosoma cruzi CYP51 as anti-Chagas agents. | [Synthesis]
Step 1: To a stirred solution of 4-bromo-2-fluorobenzoic acid (15.0 g, 68.49 mmol, 1 eq.) in methanol (150 mL) was slowly added thionyl chloride (23.09 mL, 136.9 mmol, 2 eq.) at 0 °C. The reaction mixture was kept at 0 °C for 15 minutes before being brought to room temperature and stirring was continued for 12 hours. After completion of the reaction, methanol was removed by evaporation under reduced pressure and the residue was diluted with ethyl acetate (250 mL). The organic layer was washed sequentially with saturated aqueous sodium bicarbonate solution, brine (150 mL) and deionized water (150 mL). The ethyl acetate layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure to give methyl 4-bromo-2-fluorobenzoate (15 g, 93% yield) as an off-white solid (LC-MS purity 99%; TLC conditions: ethyl acetate/petroleum ether (3:7), Rf value 0.8). | [References]
[1] Patent: WO2004/46096, 2004, A2. Location in patent: Page 38
[2] Organic Process Research and Development, 2011, vol. 15, # 3, p. 565 - 569
[3] Journal of Medicinal Chemistry, 2013, vol. 56, # 19, p. 7651 - 7668
[4] Patent: WO2015/48306, 2015, A1. Location in patent: Page/Page column 88; 112
[5] Patent: WO2013/68461, 2013, A1. Location in patent: Page/Page column 105; 106; 109 |
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