| Identification | Back Directory | [Name]
CM-4620 | [CAS]
1713240-67-5 | [Synonyms]
CM-4620
CS-2907
Benzamide, N-[5-(6-chloro-2,2-difluoro-1,3-benzodioxol-5-yl)-2-pyrazinyl]-2-fluoro-6-methyl- | [Molecular Formula]
C19H11ClF3N3O3 | [MDL Number]
MFCD30489478 | [MOL File]
1713240-67-5.mol | [Molecular Weight]
421.76 |
| Chemical Properties | Back Directory | [Boiling point ]
444.4±45.0 °C(Predicted) | [density ]
1.58±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : ≥ 100 mg/mL (237.10 mM);Water : < 0.1 mg/mL (insoluble) | [form ]
Solid | [pka]
10.06±0.70(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Zegocractin (CM-4620) is a calcium-release activated calcium-channel (CRAC channel) inhibitor, with IC50s of 119 nM and 895 nM for Orai1/STIM1 and Orai2/STIM1 channels, respectively[1]. | [in vivo]
Mouse PACs are treated with CRAC inhibitors Zegocractin or GSK-7975A and monitored for their rate of Calcium uptake. Both CRAC inhibitors reduce the rate of store-operated Calcium entry into the ER to 50% of controllevels upon treatment with 700 nM of inhibitor. Zegocractin blocks 100% of reuptake at 10 mM[1]. | [References]
[1] ARYL SULFONOHYDRAZIDES. WO2016/138472Al. |
|
| Company Name: |
Twochem Co.Ltd.
|
| Tel: |
021-58111628 15800915896 |
| Website: |
cn.twochem.com |
| Company Name: |
Cckinase, Inc.
|
| Tel: |
+1 (732)236-3202 |
| Website: |
www.cckinase.com |
|