| Identification | Back Directory | [Name]
2-Butenediamide, N1-[3-(aminocarbonyl)phenyl]-N4-methyl-, (2Z)- | [CAS]
1708103-69-8 | [Synonyms]
ARTD10/PARP10-IN-2
2-Butenediamide, N1-[3-(aminocarbonyl)phenyl]-N4-methyl-, (2Z)- | [Molecular Formula]
C12H13N3O3 | [MOL File]
1708103-69-8.mol | [Molecular Weight]
247.25 |
| Hazard Information | Back Directory | [Uses]
ARTD10/PARP10-IN-2 (compound 19) is a potent and non-selective PARP inhibitor, targeting to mono-ADP-ribosyltransferases ARTD10/PARP10 and poly(ADP-ribose) polymerase-1 ARTD1/PARP1 with IC50s of 2.0 μM, and 9.7 μM, respectively[1]. | [IC 50]
ARTD1/PARP1: 9.7 μM (IC50); ARTD10/PARP10: 2.0 μM (IC50); ARTD8/PARP14: >20 μM (IC50); ARTD7/PARP15: >20 μM (IC50) | [References]
[1] Ekblad T, et al. Towards small molecule inhibitors of mono-ADP-ribosyltransferases. Eur J Med Chem. 2015 May 5;95:546-51. DOI:10.1016/j.ejmech.2015.03.067 |
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