| Identification | Back Directory | [Name]
BLU-554 | [CAS]
1707289-21-1 | [Synonyms]
BLU-554
CS-2345
Fisogatinib
BLU-554;BLU 554
BLU554, CPDB0942
BLU554(Fisogatinib)
Fisogatinib (BLU 554)
BLU-554, 98%, a potent fibroblast growth factor receptor 4 (FGFR4) inhibitor
N-(3-{[6-(2,6-Dichloro-3,5-dimethoxyphenyl)-2-quinazolinyl]amino}tetrahydro-2H-pyran-4-yl)acrylamide
N-((3S,4S)-3-((6-(2,6-dichloro-3,5-dimethoxyphenyl)quinazolin-2-yl)amino)tetrahydro-2H-pyran-4-yl)acrylamide
2-Propenamide, N-[(3S,4S)-3-[[6-(2,6-dichloro-3,5-dimethoxyphenyl)-2-quinazolinyl]amino]tetrahydro-2H-pyran-4-yl]- | [Molecular Formula]
C24H24Cl2N4O4 | [MDL Number]
MFCD30496704 | [MOL File]
1707289-21-1.mol | [Molecular Weight]
503.38 |
| Chemical Properties | Back Directory | [density ]
1.39±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 20 mg/mL; DMSO: 20 mg/mL; DMSO:PBS (pH 7.2) (1:2): 0.3 mg/mL; Ethanol: 0.2 mg/mL | [form ]
A crystalline solid | [pka]
13.77±0.40(Predicted) | [color ]
White to light yellow |
| Hazard Information | Back Directory | [Uses]
N-[(3S,4S)-3-[[6-(2,6-Dichloro-3,5-dimethoxyphenyl)-2-quinazolinyl]amino]tetrahydro-2H-pyran-4-yl]-2-propenamide is a fibroblast growth factor receptor 4 (FGFR4) inhibitor. BLU-554 | [in vivo]
Tissue distribution of Fisogatinib (10 mg/kg; oral gavage; for 4 hours; FVB/NRj mice) in wild-type mice is as follows; tissue concentrations decreases in the order liver > kidney > small intestine > spleen > brain. The high Fisogatinib liver-to-plasma ratio suggests there is a relatively high amount of the drug being transported into the liver[1]. | Animal Model: | Wild type male mice(FVB/NRj, 11-14?weeks of age)[1] | | Dosage: | 10?mg/kg | | Administration: | Oral gavage; for 4 hours (Pharmacokinetic study) | | Result: | Tissue concentrations decreased in the order liver?>?kidney?>?small intestine?>?spleen?>?brain.
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| [IC 50]
FGFR4: 5 nM (IC50) |
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