| Identification | Back Directory | [Name]
FTI-277 | [CAS]
170006-73-2 | [Synonyms]
FTI-277
FTI-277;FTI277
METHYL[N-[2-PHENYL-4-N-[2(R)-AMINO-3-MERCAPTOPROPYLAMINO] BENZOYL]]-METHIONATE, TFA
N-[[5-[[(2R)-2-Amino-3-mercaptopropyl]amino][1,1'-biphenyl]-2-yl]carbonyl]-L-methionine methyl ester
N-[4-[2(R)-AMINO-3-MERCAPTOPROPYL]AMINO-2-PHENYLBENZOYL]METHIONINE METHYL ESTER TRIFLUOROACETATE SALT
L-Methionine, N-[[5-[[(2R)-2-amino-3-mercaptopropyl]amino][1,1'-biphenyl]-2-yl]carbonyl]-, methyl ester
N-[4-[2(R)-Amino-3-mercaptopropyl]amino-2-phenylbenzoyl]methionine methyl ester trifluoroacetate salt | [Molecular Formula]
C22H29N3O3S2 | [MDL Number]
MFCD06795840 | [MOL File]
170006-73-2.mol | [Molecular Weight]
447.61 |
| Chemical Properties | Back Directory | [Boiling point ]
684.2±55.0 °C(Predicted) | [density ]
1.222±0.06 g/cm3(Predicted) | [storage temp. ]
−20°C
| [solubility ]
H2O: soluble
| [form ]
amorphous semi-solid
| [pka]
9.81±0.10(Predicted) | [Water Solubility ]
H2O: ≥2mg/mL |
| Hazard Information | Back Directory | [Uses]
Farnesyltransferase inhibitor 277 (FTI-277) has been used to:
- inhibit protein farnesylation in breast cell lines.
- in marrow-isolated adult multilineage inducible cells (MIAMI).
- inhibition of farnesyl transferase in CV-1 in Origin with SV40 genes cells (COS-7).
| [Biochem/physiol Actions]
Farnesyltransferase inhibitor 277 (FTI-277) mediates apoptosis in multiple myeloma and is regarded as a potential therapeutic agent. | [storage]
Store at -20°C |
|
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Sigma-Aldrich
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Musechem
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www.musechem.com |
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