| Identification | Back Directory | [Name]
GNE-8324 | [CAS]
1698901-76-6 | [Synonyms]
GNE8324
GNE-8324
GNE 8324
GNE-8324; GNE 8324; GNE8324
4H,6H-Cyclopenta[4,5]thiazolo[3,2-a]pyrimidin-4-one, 2-[[ethyl(4-fluorophenyl)amino]methyl]-7,8-dihydro- | [Molecular Formula]
C18H18FN3OS | [MDL Number]
MFCD33029243 | [MOL File]
1698901-76-6.mol | [Molecular Weight]
343.42 |
| Hazard Information | Back Directory | [Description]
GNE-8324 is a potent and selective NMDA receptor PAM. | [in vitro]
This study showed previously that NMDAR positive allosteric modulator GNE-8324 and M-8324 selectively increase NMDAR activity on the inhibitory neurons and elevates their activity in vitro and in vivo._x000D_
_x000D_
Reference: Front Pharmacol. 2022 Jan 4;12:796179. https://pubmed.ncbi.nlm.nih.gov/35058780/ | [target]
GNE-8324 is a selective GluN2A positive allosteric modulator. GNE-8324 selectively enhances NMDA receptor (NMDAR)-mediated synaptic responses in inhibitory but not excitatory neurons. |
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DC Chemicals
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InvivoChem
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13549236410 |
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Biorbyt Ltd.
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www.biorbyt.com |
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