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ChemicalBook--->CAS DataBase List--->1683535-53-6

1683535-53-6

1683535-53-6 Structure

1683535-53-6 Structure
IdentificationBack Directory
[Name]

3-Aminopropyl (2,2,2-trichloro-1-(pyrimidin-2-ylamino)ethyl)carbamate hydrochloride
[CAS]

1683535-53-6
[Synonyms]

Apcin A HCL
3-Aminopropyl (2,2,2-trichloro-1-(pyrimidin-2-ylamino)ethyl)carbamate hydrochloride
[Molecular Formula]

C10H15Cl4N5O2
[MDL Number]

MFCD34167446
[MOL File]

1683535-53-6.mol
[Molecular Weight]

379.06
Safety DataBack Directory
[Symbol(GHS) ]


GHS07
[Signal word ]

Warning
[Hazard statements ]

H302-H315-H319-H335
[Precautionary statements ]

P261-P280-P301+P312-P302+P352-P305+P351+P338
Hazard InformationBack Directory
[Uses]

Apcin-A monohydrochloride, an Apcin derivative, is an anaphase-promoting complex (APC) inhibitor. Apcin-A monohydrochloride interacts strongly with Cdc20, and inhibits the ubiquitination of Cdc20 substrates. Apcin-A monohydrochloride can be used to synthesize the PROTAC CP5V (HY-130257)[1].
[References]

[1] Chi JJ, et al. A novel strategy to block mitotic progression for targeted therapy. EBioMedicine. 2019 Oct 25. pii: S2352-3964(19)30677-2. DOI:10.1016/j.ebiom.2019.10.013
Spectrum DetailBack Directory
[Spectrum Detail]

3-Aminopropyl (2,2,2-trichloro-1-(pyrimidin-2-ylamino)ethyl)carbamate hydrochloride(1683535-53-6)1HNMR
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