| Chemical Properties | Back Directory | [density ]
1.36±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | [form ]
Solid | [pka]
12.21±0.40(predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Uses]
DJ4 is a ATP-competitive inhibitor of ROCK1/2 (IC50 values:5 and 50 nM) and MRCKα/β (IC50 values:10 and 100 nM). DJ4 blocks stress fiber formation and induces cell apoptosis. DJ4 can be used for study of cancer[1]. | [IC 50]
ROCK1: 5 nM (IC50); ROCK2: 50 nM (IC50) | [References]
[1] Kale VP, et al. A novel selective multikinase inhibitor of ROCK and MRCK effectively blocks cancer cell migration and invasion. Cancer Lett. 2014;354(2):299-310. DOI:10.1016/j.canlet.2014.08.032 |
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