| Identification | Back Directory | [Name]
PNU 103017 | [CAS]
166335-18-8 | [Synonyms]
PNU 103017
Benzenesulfonamide, 4-cyano-N-[3-[cyclopropyl(5,6,7,8,9,10-hexahydro-4-hydroxy-2-oxo-2H-cycloocta[b]pyran-3-yl)methyl]phenyl]- | [Molecular Formula]
C28H28N2O5S | [MDL Number]
MFCD00942267 | [MOL File]
166335-18-8.mol | [Molecular Weight]
504.6 |
| Chemical Properties | Back Directory | [Boiling point ]
721.3±70.0 °C(Predicted) | [density ]
1.39±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [pka]
4.50±1.00(Predicted) |
| Hazard Information | Back Directory | [Uses]
PNU-103017 is an HIV protease inhibitor. | [in vivo]
PNU-103017 is a selective HIV aspartyl protease inhibitor under evaluation as a potential oral treatment of Acquired Immunodeficiency Diseases. PNU-103017 is a racemic mixture of two enantiomers, designated PNU-103264 (R-) and PNU-103265 (S-). The Cmax (P≤0.0349), Cmin (P≤0.0168), and Cav (P≤0.0118) are significantly higher for the (R)- than the (S)-enantiomer, showing enantioselective pharmacokinetics of PNU-103017 in the dog[1]. | [References]
[1] Williams MG, et al. Stereospecific determination of an HIV aspartyl protease inhibitor, PNU-103017, in rat, dog and human plasma using a Pirkle-concept high-performance liquid chromatographic column. DOI:10.1016/s0378-4347(97)00121-7 |
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