| Identification | Back Directory | [Name]
LB-100 | [CAS]
1632032-53-1 | [Synonyms]
LB-100 (1R,4S)
LB-100
(LB100)
LB-100;LB 100;LB100
endothall 4-methylpiperazine monoamide
rel-(1R,4S)-3-(4-methylpiperazine-1-carbonyl)-7-oxabicyclo[2.2.1]heptane-2-carboxylic acid
7-Oxabicyclo[2.2.1]heptane-2-carboxylic acid, 3-[(4-methyl-1-piperazinyl)carbonyl]-, (1R,4S)-rel- | [Molecular Formula]
C13H20N2O4 | [MOL File]
1632032-53-1.mol | [Molecular Weight]
268.31 |
| Chemical Properties | Back Directory | [Boiling point ]
486.9±45.0 °C(Predicted) | [density ]
1.312±0.06 g/cm3(Predicted) | [solubility ]
DMSO:54.0(Max Conc. mg/mL);201.26(Max Conc. mM) | [form ]
A crystalline solid | [pka]
4.03±0.40(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
LB-100 is a small molecule inhibitor of protein phosphatase 2A with potent chemo- and radio-sensitizing potential in variety of cancer types including pancreatic cancer and colorectal cancer of human and animal model. | [in vivo]
LB-100 (2 mg/kg, i.p.) decreases in a time-dependent manner the activity of PP2A in xenografts and livers in nude mice. LB-100 does not alter the expression of the three PP2A subunits (PP2A_A, PP2A_B, and PP2A_C) in cell lines, xenografts, or livers, as confirmed by immunoblotting. The combination of doxorubicin (1.5 kg/mL, every other day) and LB-100 (2 mg/kg, every other day) significantly slows the growth of tumors with reduction of tumor volume in two animals with no effects on tumor growth in animals treated with single agents[2]. |
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| Company Name: |
Musechem
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| Tel: |
+1-800-259-7612 |
| Website: |
www.musechem.com |
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