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ChemicalBook--->CAS DataBase List--->1631754-41-0

1631754-41-0

1631754-41-0 Structure

1631754-41-0 Structure
IdentificationBack Directory
[Name]

Hydronidone
[CAS]

1631754-41-0
[Synonyms]

Hydronidone
CD101 acetate
SP-3025 acetate
Biafungin acetate
Rezafungin acetate
[Molecular Formula]

C65H88N8O19
[MDL Number]

MFCD32899863
[MOL File]

1631754-41-0.mol
[Molecular Weight]

1285.44
Chemical PropertiesBack Directory
[form ]

Solid
[color ]

White to off-white
Hazard InformationBack Directory
[Uses]

Rezafungin acetate (Biafungin acetate) is a next-generation, broad-spectrum, and long-lasting echinocandin. Rezafungin acetate shows potent antifungal activity against Candida spp., Aspergillus spp., and Pneumocystis spp.[1][2].
[in vivo]

Rezafungin acetate (Biafungin acetate) (1 mg/kg; i.p. once daily for 6 days) shows potent in vivo efficacy as prophylaxis against Pneumocystis in a mouse infection model[1].

Animal Model:C3H/HeN mice[1]
Dosage:1 mg/kg
Administration:Intraperitoneal injection; once daily for 6 days
Result:Significantly reduced nuclei and asci burdens.
[References]

[1] Melanie Cushion, et al. Rezafungin Prophylactic Efficacy in a Mouse Model of Pneumocystis Pneumonia. VOLUME 25, ISSUE 3, SUPPLEMENT, S366, MARCH 01, 2019.
[2] Sofjan AK, et al. Rezafungin (CD101), a next-generation echinocandin: A systematic literature review and assessment of possible place in therapy. J Glob Antimicrob Resist. 2018 Sep;14:58-64. DOI:10.1016/j.jgar.2018.02.013
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