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ChemicalBook--->CAS DataBase List--->1629633-48-2

1629633-48-2

1629633-48-2 Structure

1629633-48-2 Structure
IdentificationBack Directory
[Name]

CDK8-IN-1
[CAS]

1629633-48-2
[Synonyms]

CDK8-IN-1
CDK8-IN-16
CDK8IN1,CDK-8-IN-1,CDK8 IN 1
[Molecular Formula]

C11H8F3N3O
[MOL File]

1629633-48-2.mol
[Molecular Weight]

255.2
Chemical PropertiesBack Directory
[Boiling point ]

406.2±45.0 °C(Predicted)
[density ]

1.429±0.06 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[solubility ]

Soluble in DMSO
[form ]

Solid
[pka]

12.46±0.50(Predicted)
[color ]

White to light brown
Hazard InformationBack Directory
[Description]

CDK8-IN-1 is a potent and selective CDK8 inhibitor with an IC50 of 3 nM.

CDK8-IN-1 displays low systemic clearance, very good exposure and oral bioavailability. The tmax is 0.25 h by PO. The mean values of Cmax are 9940 μg/L, 12740 μg/L by IV and PO respectively. The values of AUC are 9378, 25952 by IV and PO respectively[1].

[Uses]

CDK8-IN-1 is a potent and selective CDK8 inhibitor with an IC50 of 3 nM.
[in vivo]

CDK8-IN-1 displays low systemic clearance, very good exposure and oral bioavailability. The tmax is 0.25 h by PO. The mean values of Cmax are 9940 μg/L, 12740 μg/L by IV and PO respectively. The values of AUC are 9378, 25952 by IV and PO respectively[1].

[IC 50]

CDK8: 3 nM (IC50)
[storage]

Store at -20°C
[References]

[1]. Han X, et al. Discovery of potent and selective CDK8 inhibitors through FBDD approach. Bioorg Med Chem Lett. 2017 Sep 15;27(18):4488-4492.

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