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ChemicalBook--->CAS DataBase List--->1628353-01-4

1628353-01-4

1628353-01-4 Structure

1628353-01-4 Structure
IdentificationBack Directory
[Name]

D-myo-Inositol, 1-[(2R)-2,3-bis[(1-oxohexadecyl)oxy]propyl hydrogen phosphate] 4,5-bis(dihydrogen phosphate), sodium salt (1:3)
[CAS]

1628353-01-4
[Synonyms]

D-myo-Inositol, 1-[(2R)-2,3-bis[(1-oxohexadecyl)oxy]propyl hydrogen phosphate] 4,5-bis(dihydrogen phosphate), sodium salt (1:3)
[Molecular Formula]

C41H82NaO19P3
[MOL File]

1628353-01-4.mol
[Molecular Weight]

995
Chemical PropertiesBack Directory
[solubility ]

Chloroform: .1 mg/ml; Chloroform:Methanol:Water (3:3:1): 1 mg/ml; Water: 10 mg/ml
[form ]

A lyophilized powder
Hazard InformationBack Directory
[Description]

The phosphatidylinositol (PtdIns) phosphates represent a small percentage of total membrane phospholipids. However, they play a critical role in the generation and transmission of cellular signals.1,2 PtdIns PtdIns-(4,5)-P2 (1,2-dipalmitoyl) is a synthetic analog of natural phosphatidylinositol (PtdIns) containing C16:0 fatty acids at the sn-1 and sn-2 positions. The compound features the same inositol and diacylglycerol (DAG) stereochemistry as the natural compound. The natural compound is the product of PtdIns-4-phosphate 5-kinase acting on PtdIns-(4)-P1. Hydrolysis of PtdIns-(4,5)-P2 by phosphoinositide (PI)-specific phospholipase C generates inositol triphosphate (IP3) and DAG which are key second messengers in an intricate biochemical signal transduction cascade.
[References]

1. Exton, J.H. Regulation of phosphoinositide phospholipases by hormones, neurotransmitters, and other agonists linked to G proteins Annu. Rev. Pharmacol. Toxicol. 36,481-509(1996).
2. Majerus, P.W. Inositol phosphate biochemistry Annu. Rev. Biochem. 61,225-250(1992).
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