| Identification | Back Directory | [Name]
QGOICCMBEDDFCI-NXQGQTBASA-N | [CAS]
1623432-51-8 | [Synonyms]
AM-7209
AMG7209
AMG-7209
AMG 7209
QGOICCMBEDDFCI-NXQGQTBASA-N
Benzoic acid, 4-[[2-[(3R,5R,6S)-6-(4-chloro-3-fluorophenyl)-5-(3-chlorophenyl)-1-[(1S)-1-cyclopropyl-2-[(1,1-dimethylethyl)sulfonyl]ethyl]-3-methyl-2-oxo-3-piperidinyl]acetyl]amino]-2-methoxy- | [Molecular Formula]
C37H41Cl2FN2O7S | [MDL Number]
MFCD28902225 | [MOL File]
1623432-51-8.mol | [Molecular Weight]
747.7 |
| Hazard Information | Back Directory | [Description]
AMG-7209 is a potent and selective inhibitor of the MDM2-p53 interaction. | [Uses]
AM-7209 is a potent and selective MDM2-p53 interaction inhibitor with a Kd of 38 pM. AM-7209 inhibits the MDM2 amplified SJSA-1 osteosarcoma cell line with an IC50 of 1.6 nM. AM-7209 shows antitumor activities[1]. | [References]
[1] Yosup Rew, et al. Discovery of AM-7209, a potent and selective 4-amidobenzoic acid inhibitor of the MDM2-p53 interaction. J Med Chem. 2014 Dec 26;57(24):10499-511. DOI:10.1021/jm501550p |
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