| Identification | Back Directory | [Name]
2-Butenamide, N-[4-[(3-chloro-4-fluorophenyl)amino]-7-(2-propyn-1-yloxy)-6-quinazolinyl]-4-(dimethylamino)-, (2E)- | [CAS]
1621002-27-4 | [Synonyms]
PF-06672131 >=95% (HPLC)
2-Butenamide, N-[4-[(3-chloro-4-fluorophenyl)amino]-7-(2-propyn-1-yloxy)-6-quinazolinyl]-4-(dimethylamino)-, (2E)- | [Molecular Formula]
C23H21ClFN5O2 | [MDL Number]
MFCD28386021 | [MOL File]
1621002-27-4.mol | [Molecular Weight]
453.9 |
| Chemical Properties | Back Directory | [Boiling point ]
647.7±55.0 °C(Predicted) | [density ]
1.363±0.06 g/cm3(Predicted) | [storage temp. ]
room temp | [solubility ]
DMSO: 5mg/mL, clear (warmed) | [form ]
powder | [pka]
11.65±0.43(Predicted) | [color ]
white to beige |
| Hazard Information | Back Directory | [Description]
PF-06672131 is a selective EGFR kinase inhibitor. | [Uses]
PF-06672131 is an alkynylated afatinib derivative and a small molecule probe that is reactive to cysteine. PF-06672131 is an inhibitor of epidermal growth factor receptor (EGFR) kinase that targets the ATP pockets of EGFR. PF-06672131 can be used for activity-based protein profiling studies[1]. | [References]
[1] van Bergen W, et al. Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. DOI:10.1016/j.mcpro.2022.100455 |
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| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
|