| Chemical Properties | Back Directory | [Boiling point ]
351.6±44.0 °C(Predicted) | [density ]
1.475±0.06 g/cm3(Predicted) | [storage temp. ]
4°C, protect from light, stored under nitrogen | [solubility ]
DMSO: 125 mg/mL (705.50 mM) | [form ]
Solid | [pka]
6.04±0.69(Predicted) | [color ]
White to yellow |
| Hazard Information | Back Directory | [Uses]
Cimlanod (BMS-986231) is a second-generation Nitroxyl (HNO) donor for heart failure. Cimlanod (BMS-986231) delivers HNO via pH-dependent chemical breakdown when exposed to the neutral pH environment of the bloodstream. Cimlanod (BMS-986231) possesses positive lusitropic and inotropic as well as vasodilatory effects[1][2]. | [storage]
4°C, protect from light, stored under nitrogen | [References]
[1] Cowart D, et al. A Phase 1 Randomized Study of Single Intravenous Infusions of the Novel Nitroxyl Donor BMS-986231 in Healthy Volunteers. J Clin Pharmacol. 2019 May;59(5):717-730. DOI:10.1002/jcph.1364
[2] Felker GM, et al. Rationale and design for the development of a novel nitroxyl donor in patients with acute heart failure. Eur J Heart Fail. 2019 Aug;21(8):1022-1031. DOI:10.1002/ejhf.1504 |
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mahaloong
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| Tel: |
+86-028-81192082 +86-18180560816 |
| Website: |
https://www.mahaloong.com |
| Company Name: |
MedChemExpress
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| Tel: |
021-58955995 |
| Website: |
www.medchemexpress.com |
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