| Identification | Back Directory | [Name]
Pyridine, 2-methyl-3-[(2S)-2-pyrrolidinylmethoxy]-, dihydrochloride | [CAS]
161416-61-1 | [Synonyms]
ABT 089 dihydrochloride
Pozanicline dihydrochloride
ABT 089 dihydrochloride
(ABT089
2-Methyl-3-[(2S)-pyrrolidinylmethoxy]pyridine dihydrochloride
Pyridine, 2-methyl-3-[(2S)-2-pyrrolidinylmethoxy]-, dihydrochloride | [Molecular Formula]
C11H16N2O.2ClH | [MOL File]
161416-61-1.mol | [Molecular Weight]
265.179 |
| Chemical Properties | Back Directory | [storage temp. ]
2-8°C | [solubility ]
Soluble in DMSO | [form ]
powder | [color ]
white to beige | [optical activity]
[α]/D +20 to +30°, c = 1 in methanol |
| Hazard Information | Back Directory | [Uses]
2-Methyl-3-[(2S)-2-pyrrolidinylmethoxy]-pyridine Dihydrochloride is a selective neuronal nicotinic receptor (NNR) modulator and a neuroprotective agent that has therapeutic potential for treating cognitive disorders. 2-Methyl-3-[(2S)-2-pyrrolidinylmethoxy]-pyridine Dihydrochloride is selective for the neuronal nicotinic acetylcholine receptors (nAChRs) subtype, which modulate the release of neurotransmitters (acetylcholine and dopamine). | [in vivo]
Pozanicline (ABT-089; 0.3 mg/kg and 0.6 mg/kg) reverses nicotine withdrawal-induced deficits in contextual fear conditioning[3]. | Animal Model: | Adult male C57BL6/J mice at 8-12 weeks of age[3]. | | Dosage: | 0.3 mg/kg and 0.6 mg/kg | | Administration: | Treated 5 min before training and testing for contextual fear conditioning | | Result: | A dose of 0.3 mg/kg and 0.6 mg/kg ameliorated nicotine withdrawal-induced cognitive deficits in contextual fear conditioning. |
| [storage]
Store at -20°C |
|
| Company Name: |
BOC Sciences
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| Tel: |
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| Website: |
https://www.bocsci.com |
| Company Name: |
Energy Chemical
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| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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