| Identification | Back Directory | [Name]
2-Amino-6-chloro-9-(3-deoxy-3-fluoro-beta-D-ribofuranosyl)-9H-purine | [CAS]
1612192-05-8 | [Synonyms]
2-Amino-6-chloro-9-(3'-deoxy-3'-fluoro-b-D-ribofuranosyl)-9H-purine
2-Amino-6-chloro-9-(3-deoxy-3-fluoro-beta-D-ribofuranosyl)-9H-purine
9H-?Purin-?2-?amine, 6-?chloro-?9-?(3-?deoxy-?3-?fluoro-?β-?D-?ribofuranosyl)?- | [Molecular Formula]
C10H11ClFN5O3 | [MOL File]
1612192-05-8.mol | [Molecular Weight]
303.68 |
| Hazard Information | Back Directory | [Uses]
2-Amino-6-chloro-9-(3-deoxy-3-fluoro-beta-D-ribofuranosyl)-9H-purine ((2R,3S,4S,5R)-2-(2-Amino-6-chloro-9H-purin-9-yl)-4-fluoro-5-(hydroxymethyl)tetrahydrofuran-3-ol) is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1]. | [References]
[1] Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88. DOI:10.2174/138161212801227005 |
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