| Identification | Back Directory | [Name]
IOCETAMIC ACID (200 MG) | [CAS]
16034-77-8 | [Synonyms]
mp620
drc1201
cholimil
colebrina
iocetamic
cholebrine
iocetamicacid
IOCETAMIC ACID (200 MG)
n-acetyl-n-(3-amino-2,4,6-triiodophenl)-2-methyl-beta-alanine
n-acetyl-n-(3-amino-2,4,6-triiodophenyl)-2-methyl-beta-alanin
n-acetyl-n-(3-amino-2,4,6-triiodophenyl)-2-methyl-beta-alanine
n-acetyl-n-(3-amino-2,4,6-triiodophenyl)-beta-aminoisobutyricacid
n-acetyl-n-(2,4,6-triiodo-3-aminophenyl)-beta-aminoisobutyricacid
3-(acetyl(3-amino-2,4,6-triiodophenyl)amino)-2-methyl-propanoicaci
3-(acetyl-(3-amino-2,4,6-triiodophenyl)amino)-2-methylpropanoicacid
3-(acetyl-(3-amino-2,4,6-triiodophenyl)amino)-2-methyl-propionicaci
3-[Acetyl(3-amino-2,4,6-triiodophenyl)amino]-2-methylpropionic acid | [EINECS(EC#)]
240-173-1 | [Molecular Formula]
C12H13I3N2O3 | [MOL File]
16034-77-8.mol | [Molecular Weight]
613.957 |
| Chemical Properties | Back Directory | [Melting point ]
224-225° (NL 6515305); mp range 191-212° (Korver); Consists of 2 isomers having mps 232° and 200-201° | [Boiling point ]
658.2±55.0 °C(Predicted) | [density ]
2.2000 (rough estimate) | [refractive index ]
1.7400 (estimate) | [pka]
4.0(at 25℃) | [Stability:]
Stable. Incompatible with strong oxidizing agents. | [Water Solubility ]
5.286g/L(37 ºC) |
| Hazard Information | Back Directory | [Hazard]
Low toxicity by ingestion. | [Originator]
Cholebrine,Nicholas | [Uses]
Diagnostic aid (radiopaque medium). | [Definition]
ChEBI: 3-(N-acetyl-3-amino-2,4,6-triiodoanilino)-2-methylpropanoic acid is an aromatic amide. | [Manufacturing Process]
A mixture of equimolecular amounts of m-nitraniline (69.0 g), methacrylic
acid (43.0 g), and pyridine (39.5 g) was heated to 125°C for 20 h, and was
then poured into 500 ml water. A semi-crystalline product separated from the
liquid. The supernatant liquid was decanted and 500 ml fresh water was
added. The pH was adjusted to 7-7.5 by means of sodium hydroxide. The
precipitate was filtered with suction and washed with water. When the filtrate
was acidified with acetic acid, a precipitate of N-(3-nitrophenyl)-β-aminoisobutyric acid was formed. When filtered, washed with water and dried, it
weighed 56.0 g and had a melting point of 130°-131°C (recryst. from
alcohol). The yield was 50% based on nitraniline.
0.25 mol (56.0 g) N-(3-nitrophenyl)-β-aminoisobutyric acid, prepared as
described above, 160 ml glacial acetic acid, and 40 ml acetic anhydride were
heated 48 h to 50°C, and the reaction mixture was poured into 600 ml water.
A crystalline precipitate of N-acetyl-N-(3-nitrophenyl)-β-aminoisobutyric acid
formed gradually. When recovered, it weighed 56.0 g (84% yield). Melting
point 146°-148°C.
100.0 g N-acetyl-N-(3-nitrophenyl)-β-amino-isobutyric acid were dissolved in
1 L water and 40 ml 25% aqueous ammonia, and the solution was
hydrogenated in the presence of about 10.0 g Raney nickel at 20°C and about
450 p.s.i. until the pressure drop indicated the complete conversion of the
NO2 groups to NH2. Thus N-acetyl-N-(3-aminophenyl)-β-amino-isobutyric acid
was obtained.
The solution of N-acetyl-N-(3-aminophenyl)-β-amino-isobutyric acid was
filtered after standing overnight, mixed with an equal volume of acetic acid,
and there after with a solution of 275.0 g iodine monochloride and 200.0 g
sodium chloride in 1 L water. The mixture was kept at 50°C with stirring for
48 h. Light brown crystals of crude N-acetyl-N-(2,4,6-triiodo-3-aminophenyl)-
β-amino-isobutyric acid precipitated, were filtered off, washed with water, and
dried. They weighed 195.0 g (84.5% yield based on N-acetyl-N 3-nitrophenylp-amino-isobutyric acid). | [Brand name]
Cholebrine (Mallinckrodt). | [Therapeutic Function]
Diagnostic aid |
|
| Company Name: |
Leancare Ltd.
|
| Tel: |
+33 962096793 |
| Website: |
www.leancare.co.uk |
| Company Name: |
kemikalieimport
|
| Tel: |
+ 45 - 2034 3359 |
| Website: |
www.kemikalieimport.dk |
| Company Name: |
Camida
|
| Tel: |
+353-52-25455 |
| Website: |
www.camida.com |
|