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ChemicalBook--->CAS DataBase List--->1571076-26-0

1571076-26-0

1571076-26-0 Structure

1571076-26-0 Structure
IdentificationBack Directory
[Name]

Alanine, N-[(S)-[[(1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]phenoxyphosphinyl]-2-methyl-, 1-methylethyl ester
[CAS]

1571076-26-0
[Synonyms]

HS-10234
Tenofovir amibufenamide
Alanine, N-[(S)-[[(1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]phenoxyphosphinyl]-2-methyl-, 1-methylethyl ester
[Molecular Formula]

C22H31N6O5P
[MOL File]

1571076-26-0.mol
[Molecular Weight]

490.5
Chemical PropertiesBack Directory
[Boiling point ]

643.8±65.0 °C(Predicted)
[density ]

1.35±0.1 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[form ]

Solid
[pka]

4.21±0.10(Predicted)
[color ]

Off-white to light yellow
Hazard InformationBack Directory
[Uses]

Tenofovir amibufenamide (HS-10234), a Tenofovir prodrug, is an orally active antiviral agent. Tenofovir amibufenamide inhibits HBV, and can be used for chronic hepatitis B (CHB) study[1][2].
[References]

[1] Zhihong Liu, et al. Randomised clinical trial: 48 weeks of treatment with tenofovir amibufenamide versus tenofovir disoproxil fumarate for patients with chronic hepatitis B. Aliment Pharmacol Ther. 2021 Nov;54(9):1134-1149. DOI:10.1111/apt.16611
[2] Hong Zhang, et al. Randomised clinical trial: safety, efficacy and pharmacokinetics of HS-10234 versus tenofovir for the treatment of chronic hepatitis B infection. Aliment Pharmacol Ther. 2021 Jan;53(2):243-252. DOI:10.1111/apt.16196
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