Identification | Back Directory | [Name]
DX 9065a | [CAS]
155204-81-2 | [Synonyms]
DX9065 DX-9065 X-9065a DX 9065 DX 9065a DX-9065A HCl hydrate LJCBAPRMNYSDOP-LVCYMWGESA-N DX-9065a Hydrochloride Pentahydrate DX 9065A HCl hydrate,DX9065A HCl hydrate (alphaS)-7-(Aminoiminomethyl)-alpha-[4-[[(3S)-1-(1-iminoethyl)-3-pyrrolidinyl]oxy]phenyl]-2-naphthalenepropanoic acid hydrochloride hydrate 2-Naphthalenepropanoic acid, 7-(aMinoiMinoMethyl)-α-[4-[[(3S)-1-(1-iMinoethyl)-3-pyrrolidinyl]oxy]phenyl]-, (Hydrochloride), hydrate (1:1:5), (αS)- | [Molecular Formula]
C26H31ClN4O4 | [MDL Number]
MFCD00928183 | [MOL File]
155204-81-2.mol | [Molecular Weight]
499.01 |
Hazard Information | Back Directory | [Uses]
DX-9065a Hydrochloride Pentahydrate is used in the methods for cell transplantation therapy and use of factor Xa inhibitors for inhibiting the procoagulant activity associated with cell transplantation. | [in vivo]
After i.v. injection to rabbits, DX-9065a displays prolonged anti-factor Xa activity and inhibition of thrombin generation[1].
After p.o. administration, DX-9065a causes a reduction in tissue factor-induced mortality of mice with ED50 value of 56 mg/kg[1].
When given i.v. to rats, DX-9065a exhibits a dose-dependent antithrombotic effect against factor Xa + stasis-induced venous thrombosis (ED50 = 1.2 mg/kg i.v.), but also in an arteriovenous shunt thrombosis model (ED50 = 8.1 mg/kg i.v.) without affecting bleeding time significantly. Similar effects were obtained after s.c. or p.o. administration[1].
In rabbits, after i.v., s.c. or p.o. administration, DX-9065a inhibits stasis-induced thrombosis after injection of tissue factor with ED50 values of 0.03 mg/kg, 0.3 mg/kg and 50.5 mg/kg, respectively. DX-9065a inhibits in a dose-dependent manner endotoxin-induced venous thrombosis in the rabbit (ED50 = 0.25 mg/kg i.v.) and reduces the decrease in platelet number and circulating fibrinogen levels in an experimental model of tissue factor-induced disseminated intravascular coagulation[1].
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CHEMICAL LAND21
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82- 2 -783 - 8063 |
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www.chemicalland21.com |
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