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ChemicalBook--->CAS DataBase List--->15442-64-5

15442-64-5

15442-64-5 Structure

15442-64-5 Structure
IdentificationBack Directory
[Name]

PROTOPORPHYRINATO ZINC
[CAS]

15442-64-5
[Synonyms]

ZnPP
PROTOPORPHYRINATO ZINC
Zinc protoporphyrin trihydrate
Zinc protoporphyrin trihydrate, 95+%
PROTOPORPHYRINATO ZINC ISO 9001:2015 REACH
Zinc Protoporphyrin IX DISCONTINUED, offer Z439970
Zinc (II) Protoporphyrin IX - CAS 15442-64-5 - Calbiochem
Zinc(II) 3,3'-(3,8,13,17-tetramethyl-7,12-divinylporphyrin-2,18-diyl)dipropionate
dihydrogen [3,8,13,17-tetramethyl-7,12-divinyl-21H,23H-porphine-2,18-dipropionato(4-)-N21,N22,N23,N24]zincate(4-)
[EINECS(EC#)]

239-455-7
[Molecular Formula]

C34H32N4O4Zn
[MDL Number]

MFCD03427473
[MOL File]

15442-64-5.mol
[Molecular Weight]

626.03
Chemical PropertiesBack Directory
[RTECS ]

ZG9210300
[storage temp. ]

Store at RT
[solubility ]

DMSO : 50 mg/mL (79.87 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble)
[form ]

Crystalline
[color ]

Dark red to purple
[Water Solubility ]

Insoluble in water. Soluble in ethanol, and DMSO, pyridine, or dimethyl formamide.
[ε(extinction coefficient)]

≥10000 at 585-591nm in pyridine
≥12000 at 548-554nm in pyridine
≥135000 at 423-429nm in pyridine
[λmax]

426 nm
[Stability:]

Hygroscopic
[EPA Substance Registry System]

Zincate(2-), [7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)-.kappa.N21,.kappa.N22,.kappa.N23,.kappa.N24]-, dihydrogen, (SP-4-2)- (15442-64-5)
Safety DataBack Directory
[WGK Germany ]

3
[TSCA ]

Yes
Hazard InformationBack Directory
[Uses]

Potent and selective inhibitor of heme oxygenase (Ki=3nM), the enzyme that generates carbon monoxide (CO). Inhibits soluble guanylyl cyclase. Produces a time- and concentration-dependent inactivation of all three isoforms of nitric oxide synthase (IC50=0.8μM, 4.0μM, and 5.0μM for nNOS (NOS I), iNOS (NOS II) and eNOS (NOS III), respectively). Does not cross the blood-brain barrier. An useful tool to elucidate the role of CO in signal transduction and as a neurotransmitter.
[General Description]

A potent and selective inhibitor of heme oxygenase, the enzyme which generates carbon monoxide (CO) and biliverdin. Inhibits soluble guanylyl cyclase and produces a time- and concentration-dependent inactivation of all three isoforms of nitric oxide synthase (IC50 = 800 nM, 4 μM, and 5 μM for nNOS, iNOS, and eNOS, respectively). Inhibits relaxation induced by acetylcholine, ANP, and VIP in isolated rat aorta. Blocks interleukin-1 and prevents induction of long-term potentiation. Also useful as an indicator of iron-deficient erythropoiesis. Does not cross the blood-brain barrier.
[Biological Activity]

Inhibitor of heme oxygenase, which generates the putative neurotransmitter CO.
[Biochem/physiol Actions]

Primary Targetheme oxygenase
Spectrum DetailBack Directory
[Spectrum Detail]

PROTOPORPHYRINATO ZINC(15442-64-5)IR
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