| Identification | Back Directory | [Name]
NAC | [CAS]
154040-19-4 | [Synonyms]
NAC USP/EP/BP
61-95-α-Synuclein(human)
α-Synuclein (61-95) (human)
α-Synuclein (61-95) (human)
amyloid protein non-aβ component
AMYLOID PROTEIN NON-A BETA COMPONENT
EQVTNVGGAVVTGVTAVAQKTVEGAGSIIAAATGFV
NON-AB COMPONENT OF ALZHEIMER'S DISEASE AMYLOID
Non-Aβ Component of Alzheimer's Disease Amyloid
Non-Aβ Component of Alzheimer's Disease Amyloid
Amyloid Protein Non-Abeta Component >=80% (HPLC)
NON-BETA-AMYLOID COMPONENT OF ALZHEIMER'S DISEASE
NON-A-BETA COMPONENT OF ALZHEIMER'S DISEASE AMYLOID
Non-Aβ CoMponent of AlzheiMer's Disease AMyloid
NAC
Non-Aβ CoMponent of AlzheiMer's Disease AMyloid NAC
NON-BETA-AMYLOID COMPONENT OF ALZHEIMER'S DISEASE (NAC)
α-Synuclein (61-95) (human) trifluoroacetate salt/NAC, α-Synuclein (61-95) (human)
GLU-GLN-VAL-THR-ASN-VAL-GLY-GLY-ALA-VAL-VAL-THR-GLY-VAL-THR-ALA-VAL-ALA-GLN-LYS-THR-VAL-GLU-GLY-ALA-GLY-SER-ILE-ALA-ALA-ALA-THR-GLY-PHE-VAL
H-GLU-GLN-VAL-THR-ASN-VAL-GLY-GLY-ALA-VAL-VAL-THR-GLY-VAL-THR-ALA-VAL-ALA-GLN-LYS-THR-VAL-GLU-GLY-ALA-GLY-SER-ILE-ALA-ALA-ALA-THR-GLY-PHE-VAL-OH
H-GLU-GLN-VAL-THR-ASN-VAL-GLY-GLY-ALA-VAL-VAL-THR-GLY-VAL-THR-ALA-VAL-ALA-GLN-LYS-THR-VAL-GLU-GLY-ALA-GLY-SER-ILE-ILE-ALA-ALA-ALA-THR-GLY-PHE-VAL-OH
L-Valine, L-α-glutamyl-L-glutaminyl-L-valyl-L-threonyl-L-asparaginyl-L-valylglycylglycyl-L-alanyl-L-valyl-L-valyl-L-threonylglycyl-L-valyl-L-threonyl-L-alanyl-L-valyl-L-alanyl-L-glutaminyl-L-lysyl-L-threonyl-L-valyl-L-α-glutamylglycyl-L-alanylglycyl-L-seryl-L-isoleucyl-L-alanyl-L-alanyl-L-alanyl-L-t... | [Molecular Formula]
C141H235N39O49 | [MDL Number]
MFCD00678341 | [MOL File]
154040-19-4.mol | [Molecular Weight]
3260.61 |
| Chemical Properties | Back Directory | [Boiling point ]
2937.7±65.0 °C(predicted) | [density ]
1.296±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | [storage temp. ]
-20°C | [form ]
solid | [Sequence]
H-Glu-Gln-Val-Thr-Asn-Val-Gly-Gly-Ala-Val-Val-Thr-Gly-Val-Thr-Ala-Val-Ala-Gln-Lys-Thr-Val-Glu-Gly-Ala-Gly-Ser-Ile-Ala-Ala-Ala-Thr-Gly-Phe-Val-OH |
| Hazard Information | Back Directory | [Uses]
α-Synuclein (61-95) (human) is the hydrophobic core region of α-synuclein, and induces neuronal cell death. α-Synuclein (61-95) (human) can be used for research of neurodegenerative diseases, including Alzheimer’s disease (AD) and Parkinson’s disease (PD)[1][2]. | [Biochem/physiol Actions]
Found in the insoluble core of amyloid plaque; forms fibrils via a nucleation-dependent polymerization mechanism | [IC 50]
α-synuclein | [References]
[1] Tabner BJ, et al. Formation of hydrogen peroxide and hydroxyl radicals from A(beta) and alpha-synuclein as a possible mechanism of cell death in Alzheimer's disease and Parkinson's disease. Free Radic Biol Med. 2002 Jun 1;32(11):1076-83. DOI:10.1016/s0891-5849(02)00801-8
[2] Emadi S, et al. Inhibiting aggregation of alpha-synuclein with human single chain antibody fragments. Biochemistry. 2004 Mar 16;43(10):2871-8. |
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