| Identification | Back Directory | [Name]
N6-(4-Aminobenzyl)-N-methylcarboxamidoadenosine | [CAS]
152918-26-8 | [Synonyms]
ABMECA,AB MECA
AB-MECA HIGH AFFINITY A3 ADEN
N6-(4-AMINOBENZYL)-N-METHYLCARBOXAMIDOADENOSINE
n6-(4-aminobenzyl)-9-[5-(methylcarbonyl)-β-d-ribofuranosyl]adenine
β-D-Ribofuranuronamide, 1-[6-[[(4-aminophenyl)methyl]amino]-9H-purin-9-yl]-1-deoxy-N-methyl-
N6-(4-Aminobenzyl)-N-methylcarboxamidoadenosine, N6-(4-Aminobenzyl)-9-[5-(methylcarbonyl)-β-D-ribofuranosyl]adenine | [Molecular Formula]
C18H21N7O4 | [MDL Number]
MFCD05861375 | [MOL File]
152918-26-8.mol | [Molecular Weight]
399.4 |
| Chemical Properties | Back Directory | [density ]
1.68±0.1 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: soluble0.3mg/mL | [form ]
solid | [pka]
12.72±0.70(Predicted) | [color ]
off-white | [Water Solubility ]
45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.3mg/mL
ethanol: 1mg/mL
DMSO: 10mg/mL
dilute aqueous base: 3.5mg/mL
H2O: insoluble |
| Hazard Information | Back Directory | [Uses]
AB-MECA is a high affinity A3 adenosine receptor agonist. | [Biochem/physiol Actions]
High affinity A3 adenosine receptor agonist. | [in vivo]
AB-MECA (3 ug/kg; iv) enhances plasma histamine level in mouse[4].
AB-MECA (0.3 mg/kg; iv) enhances antigen-induced bronchoconstriction in male albino guinea pigs, weighing 180-220 g[5].
| Animal Model: | Male Balb/c mice, weighing 18-25 g[4] | | Dosage: | 3 ug/kg | | Administration: | IV; single dose | | Result: | Induced a 5.9-fold increase in histamine levels in murine plasma.
|
| [IC 50]
Adenosine A3 receptor | [storage]
Store at -20°C |
|
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