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ChemicalBook--->CAS DataBase List--->151870-74-5

151870-74-5

151870-74-5 Structure

151870-74-5 Structure
IdentificationBack Directory
[Name]

Kinsenoside
[CAS]

151870-74-5
[Synonyms]

Kinsenoside
(+)-Kinsenoside
(4R)-4-(beta-D-Glucopyranosyloxy)dihydro-2(3H)-furanone
2(3H)-Furanone, 4-(β-D-glucopyranosyloxy)dihydro-, (4R)-
(4R)-4-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxolan-2-one
[Molecular Formula]

C10H16O8
[MDL Number]

MFCD11100290
[MOL File]

151870-74-5.mol
[Molecular Weight]

264.229
Chemical PropertiesBack Directory
[Boiling point ]

570.2±50.0 °C(Predicted)
[density ]

1.59±0.1 g/cm3(Predicted)
[storage temp. ]

4°C, protect from light
[solubility ]

DMF:14.0(Max Conc. mg/mL);52.98(Max Conc. mM)
DMSO:33.0(Max Conc. mg/mL);124.89(Max Conc. mM)
PBS (pH 7.2):10.0(Max Conc. mg/mL);37.85(Max Conc. mM)
[form ]

A crystalline solid
[pka]

12.81±0.70(Predicted)
[color ]

White to light yellow
Hazard InformationBack Directory
[Description]

Kinsenoside is a glycoside originally isolated from A. formosanus that has diverse biological activities, including antihyperlipidemic, immunosuppressive, and anti-inflammatory properties. It increases lipolysis mediated by adipose triglyceride lipase and increases hydrolysis of triglycerides in C3H10T1/2 adipocytes. It also increases phosphorylation of peroxisome proliferator-activated receptor α (PPARα) and CREB as well as protein levels of SIRT1, PGC-1α, and carnitine palmitoyltransferase I. Kinsenoside downregulates the expression and phosphorylation of VEGF receptor 2 (VEGFR2) and inhibits crosstalk between the JAK2/STAT3 and PI3K/AKT signaling pathways in dendritic cells in vitro. It decreases the production of IFN-γ, IL-17, and TNF-α and increases the production of IL-10 in splenocytes isolated from mice with collagen-induced arthritis (CIA). Kinsenoside (300 mg/kg per day) decreases the expression of IL-1β, TNF-α, and matrix metalloproteinase-9 (MMP-9) and increases the expression of IL-10 in inflamed joints in a mouse model of collagen-induced arthritis and prevents paw edema and reduces the severity of arthritis.
[Uses]

Kinsenoside is an anti-hyperlipidemic agent isolated from the plant Anoect chilus.
[Definition]

ChEBI: (3R)-5-Oxotetrahydro-3-furanyl beta-D-glucopyranoside is a glycoside.
[storage]

4°C, protect from light
Spectrum DetailBack Directory
[Spectrum Detail]

Kinsenoside(151870-74-5)1HNMR
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