Identification | Back Directory | [Name]
2,2'-DIHYDROXYCHALCONE | [CAS]
15131-80-3 | [Synonyms]
2,2'-DIHYDROXYCHALCONE 2,2'-Dihydroxychalcone 2,2''-DIHYDROXYCHALCHONE trans-2,2'-dihydroxychalcone 1,3-DI(2-HYDROXYPHENYL)PROP-2-EN-1-ONE 1,3-bis(2-hydroxyphenyl)-2-propen-1-on 1,3-bis(2-hydroxyphenyl)-2-propen-1-one Chalcone, 2,2'-dihydroxy- (6ci,7ci,8ci) 1,3-Bis-(2-hydroxyphenyl)prop-2-en-1-one 2-Propen-1-one, 1,3-bis(2-hydroxyphenyl)- 2’-hydroxy-3-(o-hydroxyphenyl)-acrylophenon (E)-1,3-bis(2-hydroxyphenyl)prop-2-en-1-one Acrylophenone, 2'-hydroxy-3-(o-hydroxyphenyl)- | [Molecular Formula]
C15H12O3 | [MDL Number]
MFCD00017715 | [MOL File]
15131-80-3.mol | [Molecular Weight]
240.25 |
Chemical Properties | Back Directory | [Melting point ]
161-162°C | [Boiling point ]
447.1±45.0 °C(Predicted) | [density ]
1.286±0.06 g/cm3(Predicted) | [form ]
solid | [pka]
7.72±0.30(Predicted) |
Hazard Information | Back Directory | [Uses]
2,2′-Dihydroxychalcone, a flavonoid, is a glutathione S-transferase (GST) inhibitor with an IC50 of 28.9 μM in human colon cancer cells. 2,2′-Dihydroxychalcone induces cell cycle arrest and apoptosis in prostate cancer cells. 2,2′-Dihydroxychalcone has anticancer and anti-inflammatory properties[1][2]. | [References]
[1] Ahmed Q Haddad, et al. Antiproliferative mechanisms of the flavonoids 2,2'-dihydroxychalcone and fisetin in human prostate cancer cells. Nutr Cancer. 2010;62(5):668-81. DOI:10.1080/01635581003605524 [2] Kenneth Goh, et al. 2,2'-Dihydroxychalcone, a glutathione transferase inhibitor, sensitises human colon adenocarcinoma cells to chlorambucil and melphalan, but not to actinomycin D. Mol Med Rep. 2008 Jul-Aug;1(4):575-9. PMID:21479453 |
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