| Identification | Back Directory | [Name]
Balsalazide disodium | [CAS]
150399-21-6 | [Synonyms]
BALOFLOXACIN
Balsazide Disodium
BALSALAZIDE SODIUM
BALSALZIDE DISODIUM
Balsalazie DisodiuM
Balsalazide disodium
BALSALAZIDEDISODOUMSALT
Balsalazide (sodium hydrate)
Balsalazide Disodium Hydrate
Balsalzide disodium dihydrate
Balsalazide Disodium (200 mg)
BALSALAZIDE DISODIUM 2-HYDRATE
BALSALAZIDE DISODIUM DIHYDRATE
BALSALAZIDE DISODIUM SALT DIHYDRATE
Balsalazide Disodium Salt Dihydrate>
5-[4-(2-Carboxyethylcarbamoyl)phenylazo]salicylic Acid Disodium Salt
(E)-5-[[4-[[(2-Carboxyethyl)amino]-carbonyl]phenyl]azo-2-hydroxy-benzoic acid disodium salt
(E)-5-[[4-[[(2-CARBOXYETHYL)AMINO]CARBONYL]PHENYL]AZO]-2-HYDROXYBENZOIC ACID, DISODIUM SALT, DIHYDRATE
(3Z)-3-(2-{4-[(2-carboxyethyl)carbaMoyl]phenyl}hydrazin-1-ylidene)-6-oxocyclohexa-1,4-diene-1-carboxylic acid
Benzoic acid,5-[(1E)-2-[4-[[(2-carboxyethyl)aMino]carbonyl]phenyl]diazenyl]-2-hydroxy-,sodiuM salt, hydrate (1:2:2)
disodium 3-[[4-[(2-carboxylatoethylamino)-oxomethyl]phenyl]hydrazinylidene]-6-oxo-1-cyclohexa-1,4-dienecarboxylate dihydrate
Balsalazide disodium dihydrateQ: What is
Balsalazide disodium dihydrate Q: What is the CAS Number of
Balsalazide disodium dihydrate Q: What is the storage condition of
Balsalazide disodium dihydrate Q: What are the applications of
Balsalazide disodium dihydrate | [EINECS(EC#)]
1533716-785-6 | [Molecular Formula]
C17H13N3Na2O6 | [MDL Number]
MFCD07802815 | [MOL File]
150399-21-6.mol | [Molecular Weight]
437.31 |
| Chemical Properties | Back Directory | [Melting point ]
>195°C (dec.) | [storage temp. ]
under inert gas (nitrogen or Argon) at 2–8 °C | [solubility ]
DMSO (Slightly), Methanol (Slightly), Water (Slightly) | [form ]
Solid | [color ]
Yellow | [Merck ]
14,945 | [InChIKey]
XDCNKOBSQURQOZ-MVIJUDHYSA-L |
| Hazard Information | Back Directory | [Uses]
antiinflammatory | [Definition]
ChEBI: The dihydrate of the disodium salt of balsalazide. A prodrug, releasing the anti-inflammatory 5-aminosalicylic acid (mesalazine) in the large intestine, it is used in the treatment of ulcerative colitis. | [Indications]
Balsalazide disodium is delivered intact to the colon, where it is
cleaved by bacterial azoreduction to release equimolar
quantities of mesalamine, the therapeutically active
portion of the molecule, and 4-aminobenzoyl-β-alanine;
the latter compound is only minimally absorbed and is
largely inert. | [Brand name]
Colazal
(Salix). | [in vivo]
At the endpoint, the protein production of MIP-1β, MCP-1, IL-6, and IL-10 in the colon tissues decrease in concordance with the plasma concentrations of the cytokines. The drug-treated groups reveal lower expression of p-STAT3 compared to the CAC group. In addition, BCL2 decreases and BAX increases markedly in the BSZ+VSL#3 group[1]. Balsalazide is a new 5-aminosalicylic acid (5-ASA) containing prodrug[2]. | [IC 50]
IL-6; IL-1; STAT3 | [storage]
Store at -20°C |
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