| Identification | Back Directory | [Name]
Phosphinic acid, P-[(2S)-3-[[(1S)-1-(3,4-dichlorophenyl)ethyl]amino]-2-hydroxypropyl]-P-(phenylmethyl)- | [CAS]
150175-54-5 | [Synonyms]
Phosphinic acid, P-[(2S)-3-[[(1S)-1-(3,4-dichlorophenyl)ethyl]amino]-2-hydroxypropyl]-P-(phenylmethyl)- | [Molecular Formula]
C18H22Cl2NO3P | [MOL File]
150175-54-5.mol | [Molecular Weight]
402.25 |
| Hazard Information | Back Directory | [Description]
CGP 55845 is a potent, selective GABAB receptor antagonist (IC50 = 5 nM) that prevents agonist binding (pKi = 8.35) and inhibits GABA and glutamate release (pEC50 values are 8.08 and 7.85 respectively). | [Uses]
CGP55845 is a potent and selective GABAB receptor antagonist with activity that blocks agonist binding. The IC50 value of CGP55845 is 5 nM, indicating that it exhibits significant activity in inhibiting GABA and glutamate release. The apparent Kd of CGP55845 when forming a complex with the GABAB receptor is 30 nM, indicating its high affinity for this receptor. CGP55845 is as potent as 100 μM CGP 35348 in relieving the inhibitory effect of (R)-(-)-baclofen[1]. | [Definition]
ChEBI: [(2S)-3-[[(1S)-1-(3,4-dichlorophenyl)ethyl]amino]-2-hydroxypropyl]-(phenylmethyl)phosphinic acid is a dichlorobenzene. | [References]
[1] The action of new potent GABAB receptor antagonists in the hemisected spinal cord preparation of the rat |
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