| Identification | Back Directory | [Name]
PD-85639 | [CAS]
149838-21-1 | [Synonyms]
Benzeneacetamide, N-[3-(2,6-dimethyl-1-piperidinyl)propyl]-α-phenyl- | [Molecular Formula]
C24H32N2O | [MDL Number]
MFCD14635427 | [MOL File]
149838-21-1.mol | [Molecular Weight]
364.53 |
| Chemical Properties | Back Directory | [Boiling point ]
548.4±50.0 °C(Predicted) | [density ]
1.026±0.06 g/cm3(Predicted) | [storage temp. ]
room temp | [solubility ]
DMSO: 2mg/mL, clear (warmed) | [form ]
powder | [pka]
15.32±0.46(Predicted) | [color ]
white to beige |
| Hazard Information | Back Directory | [Uses]
PD-85639 is a voltage-gated sodium (Na+) channel blocker that has neuroprotective effects[1][2]. | [Biological Activity]
PD-85639 (PD85,639) is a voltage-gated sodium (Na+) channel blocker (75% in 10 min & >95% in 25 min blockage of Na+ current by 25 μM PD85,639; whole-cell patch clamp using primary r at brain neurons) th at is shown to target r at brain Nav1.2 with simultaneous high- and low-affinity modes of binding (EC50 = 56 nM/40% & 20 μM/60% at pH 9.05 nM/28% & 3 μM/72% at pH 7.4against 2 nM [3H]-PD85,639 for binding r at brain synaptosomes; EC50 = 17 nM/39% & 10 μM/61% using at pH 9.0 using r at brain synaptosome membranes) and a fast kinetic (t1/2 = 1.2 at 4°C<0.5 min at 25°C)competitive against the local anesthetic Na+ channel blockers tetracainebupivacaineand mepivacaineas well as Na+ channel activators veratridine and batrachotoxin (K1 = 0.26 μM against 5 nM [3H]-BTX for binding r at neocrotical membranes). | [References]
[1] A V Shindikar, et al. Design, synthesis and in vivo anticonvulsant screening in mice of novel phenylacetamides. Eur J Med Chem. 2006 Jun;41(6):786-92. DOI:10.1016/j.ejmech.2006.03.013
[2] Ioannis Roufos, et al. A Structure-Activity Relationship Study of Novel Phenylacetamides Which Are Sodium Channel Blockers. J. Med. Chem. 1996, 39, 1514-1520. |
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| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
|