| Identification | Back Directory | [Name]
Cidofovir | [CAS]
149394-66-1 | [Synonyms]
Gs-0504
Drg-0145
Unii-jil713Q00n
Cidovir Hydrate
GS 0504 Hydrate
Vistide Hydrate
HPMPC dihydrate
Cidofovir hydrate
(S)-HPMPC Hydrate
cidofovir dihyrate
Cidofovir 2-hydrate
(S)-HPMPC dihydrate
Cidofovir USP/EP/BP
Cidofovir dihydrate
Cidofovir hydrate (1:2)
HPMPC DIHYDRATE;(S)-HPMPC DIHYDRATE
Cidofovir dihydrate
(HPMPC dihydrate
(S)-1-(3-hydroxy-2-phosphonoMethoxypropyl)cytosine Hydrate
1-[(S)-3-Hydroxy-2-(phosphonoMethoxy)propyl]cytosine Hydrate
[1-(4-amino-2-oxo-1-pyrimidinyl)-3-hydroxypropan-2-yl]oxymethylphosphonic acid dihydrate
(S)-(3-(4-aMino-2-oxopyriMidin-1(2H)-yl)-1-hydroxypropan-2-yloxy)Methylphosphonic acid dihydrate
(S)-[[2-(4-AMino-2-oxo-1(2H)-pyriMidinyl)-1-(hydroxyMethyl)ethoxy]Methyl]phosphonic Acid Hydrate
[[(1S)-2-(4-AMino-2-oxo-1(2H)-pyriMidinyl)-1-(hydroxyMethyl)ethoxy]Methyl]phosphonic Acid Hydrate
(S)-[1-(4-AMino-2-oxo-pyriMidin-1(2H)-yl)-3-hydroxy-propan-2-yl]oxyMethylphosphonic acid dihydrate
P-[[(1S)-2-(4-Amino-2-oxo-1(2H)-pyrimidinyl)-1-(hydroxymethyl)ethoxy]methyl]phosphonic acid dihydrate
Phosphonic acid, ((2-(4-amino-2-oxo-1(2H)-pyrimidinyl)-1-(hydroxymethyl)ethoxy)methyl)-, dihydrate, (S)-
P-[[(1S)-2-(4-Amino-2-oxo-1(2H)-pyrimidinyl)-1-(hydroxymethyl)ethoxy]methyl]phosphonic acid hydrate (1:2)
Phosphonic acid,P-[[(1S)-2-(4-aMino-2-oxo-1(2H)-pyriMidinyl)-1-(hydroxyMethyl)ethoxy]Methyl]-,hydrate (1:2) | [EINECS(EC#)]
814-987-8 | [Molecular Formula]
C8H14N3O6P | [MOL File]
149394-66-1.mol | [Molecular Weight]
279.187 |
| Chemical Properties | Back Directory | [Melting point ]
>250°C (dec.) | [storage temp. ]
Keep in dark place,Inert atmosphere,2-8°C | [solubility ]
DMSO (Sparingly), Water (Sparingly) | [form ]
Solid | [color ]
White | [InChI]
InChI=1/C8H14N3O6P/c9-7-1-2-11(8(13)10-7)3-6(4-12)17-5-18(14,15)16/h1-2,6,12H,3-5H2,(H2,9,10,13)(H2,14,15,16)/t6-/s3 | [InChIKey]
VWFCHDSQECPREK-ISZMHOAENA-N | [SMILES]
N1C(=O)N(C[C@@H](CO)OCP(O)(=O)O)C=CC=1N |&1:5,r| |
| Hazard Information | Back Directory | [Chemical Properties]
White Solid | [Uses]
An injectable antiviral medication for the treatment of cytomegalovirus (CMV) retinitis in patients with AIDS. It suppresses CMV replication by selective inhibition of viral DNA polymerase and therefo
re prevention of viral replication and transcription. It is used in the treatment of acyclovir resistant herpes as well as a complementary intralesional therapy against papillomatosis caused by human
papillomavirus (HPV). | [Definition]
ChEBI: The dihydrate of the anhydrous form of cidofovir. A nucleoside analogue, it is an injectable antiviral used for the treatment of cytomegalovirus (CMV) retinitis in AIDS patients. | [Brand name]
Vistide
(Gilead Sciences). | [in vivo]
Cidofovir (subcutaneous injection, 100 mg/kg, 3-6 days interval, 21 days) dihydrate is highly protective against death from cowpox virus (CPV) infection at high doses in female weanling BALB/c mice[2].
| Animal Model: | Female weanling BALB/c mice infected with cowpox virus (CPV)[2] | | Dosage: | 100 mg/kg | | Administration: | Subcutaneous injection; 3-6 days interval; 21 days | | Result: | Prevented 80-100% of mouse deaths when administered on the first 4-3 days before infection.
Protected 35-50% of mice when administered on the fourth day after infection, and 10-20% when administered on the sixth day. |
| [storage]
Store at -20°C |
|
|