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ChemicalBook--->CAS DataBase List--->1467157-21-6

1467157-21-6

1467157-21-6 Structure

1467157-21-6 Structure
IdentificationBack Directory
[Name]

Durlobactam sodium salt (Synonyms: ETX2514)
[CAS]

1467157-21-6
[Synonyms]

ETX2514
Durlobactam sodium salt
Durlobactam sodium salt (Synonyms: ETX2514)
[Molecular Formula]

C8H12N3NaO6S
[MDL Number]

MFCD31813710
[MOL File]

1467157-21-6.mol
[Molecular Weight]

301.25
Chemical PropertiesBack Directory
[form ]

Solid
[color ]

White to light yellow
Hazard InformationBack Directory
[Uses]

Durlobactam sodium salt (ETX2514) is a broad-spectrum β-lactamase inhibitor with IC50s of 4, 14 and 190 nM for Class A KPC-2, Class C AmpC and Class D OXA-24, respectively. For the treatment of drug-resistant Gram-negative bacteria including Acinetobacter baumannii[1].
[in vivo]

Durlobactam sodium salt (ETX2514) (50 mg/kg, 200 mg/kg; sc; single dose) effectively inhibits Acinetobacter baumannii in a neutropenic mouse thigh infection model (mice carrying blaTEM-1, blaADC-82, blaOXA-23, and blaOXA-66)[3].

[References]

[1] Durand-Réville TF, et al. ETX2514 is a broad-spectrum β-lactamase inhibitor for the treatment of drug-resistant Gram-negative bacteria including Acinetobacter baumannii. Nat Microbiol. 2017 Jun 30;2:17104. DOI:10.1038/nmicrobiol.2017.104
[2] González-Bello C. Recently developed synthetic compounds with anti-infective activity. Curr Opin Pharmacol. 2019 Oct;48:17-23. DOI:10.1016/j.coph.2019.03.004
[3] Barnes MD, et al. Targeting Multidrug-Resistant Acinetobacter spp.: Sulbactam and the Diazabicyclooctenone β-Lactamase Inhibitor ETX2514 as a Novel Therapeutic Agent. mBio. 2019 Mar 12;10(2):e00159-19. DOI:10.1128/mBio.00159-19
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