| Identification | Back Directory | [Name]
BisindolylMaleiMide XI Hydrochloride | [CAS]
145333-02-4 | [Synonyms]
Bisindoylmaleimide XI
Ro-32-0432 - CAS 145333-02-4 - Calbiochem
3-(8-[(Dimethylamino)methyl]-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl)-4-(1-methylindol-3-yl)maleimide hydrochloride
3-[8-[(dimethylamino)methyl]-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-methylindol-3-yl)pyrrole-2,5-dione:hydrochloride
3-[8-[(Dimethylamino)methyl]-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione monohydrochloride | [Molecular Formula]
C28H29ClN4O2 | [MOL File]
145333-02-4.mol | [Molecular Weight]
489.008 |
| Hazard Information | Back Directory | [Uses]
Bisindolylmaleimide XI is a potent and selective cell-permeable protein kinase C (PKC) inhibitor. Studies reveal that inhibition of PKCα by Bisindolylmaleimide XI and other similar PKC inhibitors has been associated with enhanced cardiac contractility and protection from heart failure. Bisindolylmaleimide XI has been shown to prevent T-cell activation and proliferation associated with chronic inflammatory responses in vivo. | [Biological Activity]
Cell permeable: yes''Primary Target
PKCα''Product does not compete with ATP.''Reversible: no''Target IC50: 9 nM28 nM108 nMagainst PKCαPKCβIand PKCεrespectively | [in vivo]
Oral administration of Bisindolylmaleimide XI hydrochloride inhibits subsequent phorbol ester-induced edema in ratss. Induction of more physiologically T-cell driven responses such as host vs. graft responses and the secondary paw swelling in adjuvant-induced arthritis are also inhibited by Bisindolylmaleimide XI hydrochloride[2]. | [IC 50]
PKC-α: 9 nM (IC50); PKC-βI: 28 nM (IC50); PKC-βII: 31 nM (IC50); PKC-γ: 37 nM (IC50); PKC-ε: 108 nM (IC50) | [storage]
Store at -20°C |
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| Company Name: |
BOC Sciences
|
| Tel: |
1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
| Company Name: |
BOC Sciences
|
| Tel: |
16314854226 |
| Website: |
www.bocsci.com |
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
Merck Millipore
|
| Tel: |
1-400-889-1988 400-889-1988 |
| Website: |
http://www.merckmillipore.com |
| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
|