| Identification | Back Directory | [Name]
REVEROMYCIN D | [CAS]
144860-70-8 | [Synonyms]
REVEROMYCIN D
Butanedioic acid, 1-[(2S,3R,6S,8R,9S)-8-[(2E,4E,6S,7S,8E)-9-carboxy-6-hydroxy-3,7-dimethyl-2,4,8-nonatrien-1-yl]-2-[(1E,3E)-4-carboxy-3-methyl-1,3-butadien-1-yl]-9-methyl-3-pentyl-1,7-dioxaspiro[5.5]undec-3-yl] ester | [Molecular Formula]
C37H54O11 | [MDL Number]
MFCD08061900 | [MOL File]
144860-70-8.mol | [Molecular Weight]
674.82 |
| Chemical Properties | Back Directory | [Boiling point ]
855.3±65.0 °C(Predicted) | [density ]
1.20±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
White to tan solid. | [pka]
4.36±0.17(Predicted) |
| Hazard Information | Back Directory | [Description]
Reveromycin D is a bacterial metabolite originally isolated from Streptomyces. It inhibits EGF-induced mitogenic activity in Balb/MK cells and has pH-dependent antifungal activity against C. albicans (MICs = 2 and >500 μg/ml at pH 3 and 7.4, respectively). Reveromycin D also inhibits proliferation of KB and K562 cells (IC50s = 1.6 and 1.3 μg/ml, respectively). | [Uses]
Reveromycin D is a minor component of the reveromycin complex. | [Uses]
Reveromycin D is the isopentyl analogue and a minor component of the reveromycin complex, isolated from a Streptomyces sp.. Published information on reveromycin D suggests that it is more active than its straight chain analogue, reveromycin C. |
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