1448452-21-8

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1448452-21-8 Structure

Identification	Back Directory
[Name] TP receptor antagonist-1
[CAS] 1448452-21-8
[Synonyms] TP receptor antagonist-1
[Molecular Formula] C17H16ClN3O4S
[MOL File] 1448452-21-8.mol
[Molecular Weight] 393.85

Chemical Properties	Back Directory
[Melting point ] 168-170 °C
[density ] 1.43±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
[pka] 4.50±0.10(predicted)

Hazard Information	Back Directory
[Uses] TP receptor antagonist-1 (compound 7m) is a thromboxane A2 receptor (TP receptor) antagonist, with IC50 values of 9.46 μM for TPa and 8.49 μM for TPb, respectively. TP receptor antagonist-1 can be used for the research of cardiovascular disease[1].
[IC 50] Thromboxane A2 receptor α (TPa): 9.46 μM (IC₅₀); Thromboxane A2 receptor β (TPb): 8.49 μM (IC₅₀)
[References] [1] Bambi-Nyanguile SM, et al. Synthesis and pharmacological evaluation of 2-aryloxy/arylamino-5-cyanobenzenesulfonylureas as novel thromboxane A? receptor antagonists. Eur J Med Chem. 2013 Jul;65:32-40. DOI:10.1016/j.ejmech.2013.04.033

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