| Identification | Back Directory | [Name]
Ledipasvir (acetone) | [CAS]
1441674-54-9 | [Synonyms]
GS5885 acetone
GS-5885 acetone
GS 5885 acetone
Ledipasvir (acetone)
Ledipasvir acetone solvate
Ledipasvir Acetone Adducts
Ledipasvir acetone complex
Ledipasvir(GS-5885) acetone
Ledipasvir compd. with acetone
Ledipasvir Mono Acetone Solvate
Ledipasvir acetone solvate(W.S)
Mono Acetone Solvate of Ledipasvir
Carbamic acid,N-[(1S)-1-[[(6S)-6-[5-[9,9-difluoro-7-[2-[(1R,3S,4S)-2-[(2S)-2-[(methoxycarbonyl)amino]-3-methyl-1-oxobutyl]-2-azabicyclo[2.2.1]hept-3-yl]-1H-benzimidazol-6-yl]-9H-fluoren-2-yl]-1H-imidazol-2-yl]-5-azaspiro[2.4]hept-5-yl]carbonyl]-2-methylpr
Carbamic acid,N-[(1S)-1-[[(6S)-6-[5-[9,9-difluoro-7-[2-[(1R,3S,4S)-2-[(2S)-2-[(methoxycarbonyl)amino]-3-methyl-1-oxobutyl]-2-azabicyclo[2.2.1]hept-3-yl]-1H-benzimidazol-6-yl]-9H-fluoren-2-yl]-1H-imidazol-2-yl]-5-azaspiro[2.4]hept-5-yl]carbonyl]-2-methylpropyl]-,methyl ester,compd.with 2-propanone(1:1) | [Molecular Formula]
C52H60F2N8O7 | [MDL Number]
MFCD28167732 | [MOL File]
1441674-54-9.mol | [Molecular Weight]
947.1 |
| Hazard Information | Back Directory | [Uses]
Ledipasvir acetone (GS-5885 acetone) is the active ingredient of Ledipasvir. Ledipasvir is an inhibitor of the hepatitis C virus NS5A, with EC50 values of 34 pM against GT1a and 4 pM against GT1b replicon. | [References]
[1] Link JO, et al. Discovery of ledipasvir (GS-5885): a potent, once-daily oral NS5A inhibitor for the treatment of hepatitis C virus infection. J Med Chem. 2014 Mar 13;57(5):2033-46. DOI:10.1021/jm401499g |
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